Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment.
Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment.
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DOI：
10.1186/s40425-017-0230-9
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发表时间：
2017
影响因子：
10.9
通讯作者：
Maus MV
中科院分区：
文献类型：
--
作者：
Scarfò I;Maus MV
嵌合抗原受体（CAR）T细胞疗法代表了血液恶性肿瘤（即B-ALL）的革命性治疗。然而，这种类型的治疗尚未在实体瘤中取得成功。一种假设是肿瘤微环境（TME）的免疫抑制性质影响并影响过继免疫治疗的疗效。了解TME的作用及其与CAR T细胞的相互作用对于提高过继免疫治疗的效力至关重要。在这篇综述中，我们讨论了最近在小鼠模型中开发的策略和潜在的组合方法，以提高CAR T细胞的功效，特别强调这些方法的翻译潜力。
Chimeric antigen receptor (CAR) T-cell therapy represents a revolutionary treatment for haematological malignancies (i.e. B-ALL). However, the success of this type of treatment has not yet been achieved in solid tumors. One hypothesis is that the immunosuppressive nature of the tumor microenvironment (TME) influences and affects the efficacy of adoptive immunotherapy. Understanding the role of the TME and its interaction with CAR T-cells is crucial to improve the potency of adoptive immunotherapy. In this review, we discuss the strategies and potential combinatorial approaches recently developed in mouse models to enhance the efficacy of CAR T-cells, with particular emphasis on the translational potential of these approaches.