Molecular evolution of protein atomic composition
Molecular evolution of protein atomic composition
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DOI：
10.1126/science.1061052
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发表时间：
2001-07-13
期刊：
影响因子：
56.9
通讯作者：
Thomas, D
中科院分区：
文献类型：
--
作者：
Baudouin-Cornu, P;Surdin-Kerjan, Y;Thomas, D
生物体在其栖息地遇到各种生长条件，提出了生态波动是否会改变生物大分子的问题。全基因组序列的出现和整个代谢途径的表征使我们能够寻找这样的生态印记。原子组成和代谢功能之间的显着相关性被发现在硫和碳同化酶，这似乎耗尽硫和碳，分别在细菌大肠杆菌和真核生物酿酒酵母，除了遗传指令，基因组数据，从而也提供了古生物学记录的环境营养物质的可用性和代谢成本。
Living organisms encounter various growth conditions in their habitats, raising the question of whether ecological fluctuations could alter biological macromolecules. The advent of complete genome sequences and the characterization of whole metabolic pathways allowed us to search for such ecological imprints. Significant correlations between atomic composition and metabolic function were found in sulfur- and carbon-assimilatory enzymes, which appear depleted in sulfur and carbon, respectively, in both the bacterium Escherichia coli and the eukaryote Saccharomyces cerevisiae, In addition to genetic instructions, genomic data thus also provide paleontological records of environmental nutrient availability and of metabolic costs.