Unconventional protein post-translational modifications: the helmsmen in breast cancer.
Unconventional protein post-translational modifications: the helmsmen in breast cancer.
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非常规蛋白质翻译后修饰：乳腺癌的舵手
DOI：
10.1186/s13578-022-00756-z
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发表时间：
2022-02-25
影响因子：
7.5
通讯作者：
Pang D
中科院分区：
文献类型：
--
作者：
Liu J;Wang Q;Kang Y;Xu S;Pang D
乳腺癌是最常见的恶性肿瘤，也是全世界女性死亡的主要原因。乳腺癌的发生和发展涉及复杂的病理生理过程，这些过程可能是由蛋白质的翻译后修饰（PTM）介导的，受到各种基因和信号通路的刺激。对PTM的研究长期以来主要是对蛋白磷酸化和组蛋白表观遗传修饰的研究。然而，随着蛋白质组学技术的进步，其他一些PTM，如乙酰化，糖基化，sumoylation，甲基化，泛素化，瓜氨酸和棕榈酰化已被证实在乳腺癌中。然而，这些非常规的PTM（特别是磷酸化以外的非组蛋白修饰）的机制、作用和抑制剂受到的关注相对较少。因此，在这篇综述中，我们阐述了这些PTM的功能，并强调其对乳腺癌的发生和进展的影响。因此，寻找靶向PTMs的新型治疗药物和开发乳腺癌的生物学标志物，对乳腺癌患者有效的治疗方案选择和预后预测具有重要意义。在线版本包含补充材料，可通过10.1186/s13578-022-00756-z获得。
Breast cancer is the most prevalent malignant tumor and a leading cause of mortality among females worldwide. The tumorigenesis and progression of breast cancer involve complex pathophysiological processes, which may be mediated by post-translational modifications (PTMs) of proteins, stimulated by various genes and signaling pathways. Studies into PTMs have long been dominated by the investigation of protein phosphorylation and histone epigenetic modifications. However, with great advances in proteomic techniques, several other PTMs, such as acetylation, glycosylation, sumoylation, methylation, ubiquitination, citrullination, and palmitoylation have been confirmed in breast cancer. Nevertheless, the mechanisms, effects, and inhibitors of these unconventional PTMs (particularly, the non-histone modifications other than phosphorylation) received comparatively little attention. Therefore, in this review, we illustrate the functions of these PTMs and highlight their impact on the oncogenesis and progression of breast cancer. Identification of novel potential therapeutic drugs targeting PTMs and development of biological markers for the detection of breast cancer would be significantly valuable for the efficient selection of therapeutic regimens and prediction of disease prognosis in patients with breast cancer. The online version contains supplementary material available at 10.1186/s13578-022-00756-z.
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通讯作者：
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影响因子：
30.5
作者：
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通讯作者：
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