Clear association between serum levels of adipokines and T-helper 17-related cytokines in patients with psoriasis
Clear association between serum levels of adipokines and T-helper 17-related cytokines in patients with psoriasis
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DOI：
10.1111/j.1365-2230.2012.04465.x
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发表时间：
2013-01-01
影响因子：
4.1
通讯作者：
Sano, S.
中科院分区：
文献类型：
--
作者：
Nakajima, H.;Nakajima, K.;Sano, S.
背景银屑病代表T辅助细胞（Th）17介导的自身免疫性疾病之一，并已显示与代谢综合征（MetS）相关。已有研究表明银屑病患者体内存在脂肪因子和Th 17相关细胞因子的改变。瞄准研究银屑病患者与健康对照者血清中脂肪因子和Th 17相关细胞因子水平之间的关系。方法.采用ELISA法检测30例银屑病患者和30例正常人血清中脂肪因子和Th 17相关细胞因子的水平。使用Pearson相关分析确定每种脂肪因子和每种细胞因子之间的关联。还使用所有脂肪因子和Th 17相关细胞因子作为协变量进行了多元回归分析。结果Pearson相关分析显示，在正常对照组中，chemerin和adiponectin水平之间以及脂联素和高分子量脂联素之间存在强正相关。相比之下，在银屑病患者中，cDNAn水平与肿瘤坏死因子-a显著正相关，而视黄醇结合蛋白-4和白细胞介素（IL）-6水平之间存在强烈的负相关性。有趣的是，在银屑病患者中也发现了IL-22和脂联素之间的显著正相关。银屑病患者瘦素水平与IL-6呈正相关，但未达到显著性。多元回归分析确定的相关性几乎相同的皮尔逊分析。结论.这些数据表明脂肪因子和Th 17细胞因子之间的独特相互作用参与了银屑病的发病机制。
Background. Psoriasis represents one of the T-helper (Th)17-mediated autoimmune diseases, and has been shown to be associated with metabolic syndrome (MetS). It has been reported that some adipokines and Th17-related cytokines are altered in patients with psoriasis. Aim. To examine the relationship between levels of adipokines and Th17-related cytokines in the serum of patients with psoriasis compared with healthy controls. Methods. We enrolled 30 patients with psoriasis and 30 normal controls in the study, and used ELISA to measure serum adipokines and Th17-related cytokines. The association between each adipokine and each cytokine was determined using Pearson correlation analysis. Multiple regression analysis using all adipokines and Th17-related cytokines as covariates was also performed. Results. Pearson correlation analysis showed a strong positive association between chemerin and resistin levels and between adiponectin and high molecular weight adiponectin in normal controls. By contrast, in patients with psoriasis, resistin levels were significantly positively associated with tumour necrosis factor-a, while there was a strong negative association between retinol binding protein-4 and interleukin (IL)-6 levels. Interestingly, a marked positive correlation between IL-22 and adiponectin was also found in patients with psoriasis. Leptin levels correlated positively with IL-6 in patients with psoriasis, but this did not reach significance. The correlations identified by the multiple regression analyses were almost identical to those from the Pearson analyses. Conclusions. These data suggest that distinct interaction between adipokines and Th17 cytokines is involved in the pathogenesis of psoriasis.