A role for niches in hematopoietic cell development
A role for niches in hematopoietic cell development
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DOI：
10.1080/10245330500067249
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发表时间：
2005-06-01
期刊：
影响因子：
1.9
通讯作者：
Hattori, K
中科院分区：
文献类型：
--
作者：
Heissig, B;Ohki, Y;Hattori, K
干细胞存在于一个物理生态位，一个特定的微环境中。细胞小生境的组织已被证明在调节正常干细胞分化、维持和再生方面发挥关键作用。造血干细胞（HSC）出现在不同的分配领土在个体发育，特别是性腺区域，胎儿肝脏。成体HSC仅在骨髓（BM）中扩增和分化。它们可以被动员到血液中。这意味着干细胞不是自主发育的单位;相反，组织特异性小生境控制着它们的命运。HSC与其干细胞龛的相互作用对于BM中的成人造血至关重要。小生境由基质细胞组成，其通过直接细胞与细胞接触或通过释放可溶性因子维持干细胞的典型特征，主要是干细胞静止、维持或扩增。造血干细胞在干细胞龛中维持着静止和自我更新的平衡，维持着长期的造血功能，因此，了解干细胞龛的细胞和化学结构对于理解干细胞的行为至关重要。本文综述了干细胞生态位的最新进展，特别是对HSC生态位的理解。
Stem cells reside in a physical niche, a particular microenvironment. The organization of cellular niches has been shown to play a key role in regulating normal stem cell differentiation, maintenance and regeneration. Hematopoietic stem cells (HSC) emerge at distinct allocation territories during ontogenesis, notably the aorto-gonadal region, the fetal liver. Adult HSC expand and differentiate exclusively in the bone marrow (BM). They can be mobilized into the blood stream. This implies that stem cells are not autonomous units of development; rather, tissue specific niches control their destiny. Interaction of HSCs with their stem cell niches is critical for adult hematopoiesis in the BM. A niche is composed of stromal cells, which either through direct cell-to-cell contact or via release of soluble factors maintain the typical features of stem cells, mainly stem cell quiescence, maintenance or expansion. HSCs are keeping the balance of the quiescence and the self-renewal in the stem cell niche, and are maintaining long-term hematopoiesis.Therefore, an understanding of cellular and chemical architecture of the stem cell niche is vital in understanding stem cell behavior. This review summarizes the recent developments in our understanding of the stem cell niche with particular focus on the HSC niche.