EFFECTS OF L-DOPA ON NOREPINEPHRINE METABOLISM IN BRAIN
EFFECTS OF L-DOPA ON NOREPINEPHRINE METABOLISM IN BRAIN
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DOI：
10.1073/pnas.68.3.662
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发表时间：
1971-01-01
影响因子：
11.1
通讯作者：
WURTMAN, RJ
中科院分区：
文献类型：
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作者：
CHALMERS, JP;BALDESSARINI, RJ;WURTMAN, RJ
大鼠脑池内注射[3 H]去甲肾上腺素，5分钟后腹腔注射L-多巴（100 mg/kg），在随后的24小时内每隔一段时间处死一次，测定其脑内的去甲肾上腺素、L-多巴、S-腺苷甲硫氨酸和[3 H]去甲肾上腺素及其代谢产物。与对照组相比，接受L-多巴的大鼠脑内S-腺苷甲硫氨酸和[3 H]去甲肾上腺素O-甲基化代谢物的浓度明显降低。在接受L-多巴的动物中还观察到脑去甲肾上腺素含量增加（15-40%）和脑去甲肾上腺素转换加速。这些变化都是短暂的，持续约1小时，与大脑中可检测到大量左旋多巴的时间一致。
Rats received intracisternal [3H]norepinephrine and, after 5 min, intraperitoneal L-dopa (100 mg/kg); they were killed at intervals during the subsequent 24 hr. Their brains were assayed for norepinephrine, L-dopa,S-adenosylmethionine, and [3H]norepinephrine and its metabolites. Rats that received L-dopa had markedly lower brain concentrations ofS-adenosylmethionine and ofO-methylated metabolites of [3H]norepinephrine than controls. An increase (15-40%) in brain norepinephrine content and accelerated turnover of brain norepinephrine was also observed in the animals receivingL-dopa. These changes were all transient, lasting about 1 hr and coinciding with the period when appreciable amounts of L-dopa were detectable in the brain.