Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications.
Topical Vitamin C and the Skin: Mechanisms of Action and Clinical Applications.
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外用维生素 C 与皮肤：作用机制和临床应用。
DOI：
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
N. Y. Chiang
中科院分区：
文献类型：
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作者：
F. Al‐Niaimi;N. Y. Chiang
目的：这篇综述文章详细介绍了局部维生素C在皮肤上的主要作用机制和临床应用，包括其抗氧化、光保护、抗衰老和抗色素沉着作用。产品设计：使用以下关键词进行PubMed搜索维生素C和皮肤的相关文章：“维生素C”，“抗坏血酸”，“抗坏血酸-6-棕榈酸酯”和“抗坏血酸磷酸镁”。“结果：作为皮肤中最强大的抗氧化剂之一，维生素C已被证明可以防止光老化，紫外线诱导的免疫抑制和光致癌作用。它还通过增加胶原蛋白合成、稳定胶原蛋白纤维和减少胶原蛋白降解而具有抗衰老作用。它减少黑色素的形成，从而减少色素沉着。维生素C是维生素E的主要代谢物，与维生素E协同作用，防止氧化损伤。结论：外用维生素C具有广泛的临床应用，从抗衰老、抗色素沉着到光防护。目前，关于维生素C局部制剂功效的临床研究仍然有限，挑战在于找到最稳定和最具渗透性的制剂以实现最佳效果。
OBJECTIVE: This review article details the main mechanisms of action and clinical applications of topical vitamin C on the skin, including its antioxidative, photoprotective, antiaging, and antipigmentary effects. DESIGN: A PubMed search for the relevant articles on vitamin C and the skin was conducted using the following key words: "vitamin C," "ascorbic acid," "ascorbyl-6-palmitate,"and "magnesium ascorbyl phosphate." RESULTS: As one of the most powerful antioxidants in the skin, vitamin C has been shown to protect against photoaging, ultraviolet-induced immunosuppression, and photocarcinogenesis. It also has an antiaging effect by increasing collagen synthesis, stabilizing collagen fibers, and decreasing collagen degradation. It decreases melanin formation, thereby reducing pigmentation. Vitamin C is the primary replenisher of vitamin E and works synergistically with vitamin E in the protection against oxidative damage. CONCLUSION: Topical vitamin C has a wide range of clinical applications, from antiaging and antipigmentary to photoprotective. Currently, clinical studies on the efficacy of topical formulations of vitamin C remain limited, and the challenge lies in finding the most stable and permeable formulation in achieving the optimal results.