Association of study type, sample size, and follow-up length with type of recommendation produced by the National Institute for Health and Clinical Excellence Interventional Procedures Programme
Association of study type, sample size, and follow-up length with type of recommendation produced by the National Institute for Health and Clinical Excellence Interventional Procedures Programme
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DOI：
10.1017/s026646230705163x
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发表时间：
2007-12-01
影响因子：
3.2
通讯作者：
Lyratzopoulos, Georgios
中科院分区：
文献类型：
--
作者：
Campbell, William Bruce;Barnes, Steven J.;Lyratzopoulos, Georgios
目的：临床证据的类型和数量与美国国立卫生与临床优化研究所（National Institute for Health and Clinical Excellence）对介入治疗的推荐类型之间的相关性进行了研究。方法：对736项研究（包括183,729例患者）涉及130种不同介入治疗的证据和相关推荐进行了分析。研究了推荐类型（“正常安排”或“警示指导”）与证据类型、治疗患者总数和平均随访时间之间的关系。证据类型分为（a）随机、（B）非随机对照和（c）病例系列/报告。主要结果的措施是频率的证据类型，治疗的患者总数，平均随访时间，按类型的recommendation.Results：“正常安排”的建议，70（54%）的程序和“警示指导”发出60（46%）的程序。至少有一项随机研究（34%，n = 44）支持的程序更有可能接受“正常安排”的建议（相对风险1.38，p =.063）。总体而言，分别有85项（12%）、135项（18%）和516项（70%）研究属于a-c类。接受“正常安排”手术的患者人数（中位数，605;范围，26- 6，842）明显多于接受“谨慎指导”手术的患者人数（中位数，240;范围，1- 3，261; p
Objectives: The association between type and amount of clinical evidence and type of National Institute for Health and Clinical Excellence recommendations for interventional procedures was examined.Methods: The evidence about 736 studies (including 183,729 patients) relating to 130 different interventional procedures and about relevant recommendations was analyzed. Associations were examined between type of recommendation ("normal arrangements" or "cautionary guidance") and evidence type, total number of treated patients, and mean follow-up length. Evidence type was categorized as (a) randomized, (b) nonrandomized controlled, and (c) case series/reports. The main outcome measures were frequency of evidence type, total number of patients treated, and mean follow-up length, by type of recommendation.Results: "Normal arrangements" recommendations were made for 70 (54 percent) procedures and "cautionary guidance" was issued for 60 (46 percent) procedures. Procedures supported by at least one randomized study (34 percent, n = 44) were more likely to receive a "normal arrangements" recommendation (relative risk 1.38, p =.063). Overall, there were 85 (12 percent), 135 (18 percent), and 516 (70 percent) studies in categories a-c, respectively. The number of treated patients was significantly larger among procedures with "normal arrangements" (median, 605; range, 26-6,842) than among those with "cautionary guidance" (median, 240; range, 1-3,261; p