Impact of anti-Giardia and anthelminthic treatment on infant growth and intestinal permeability in rural Bangladesh: a randomised double-blind controlled study
Impact of anti-Giardia and anthelminthic treatment on infant growth and intestinal permeability in rural Bangladesh: a randomised double-blind controlled study
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DOI：
10.1016/j.trstmh.2008.07.020
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发表时间：
2009-05-01
影响因子：
2.2
通讯作者：
Lunn, Peter G.
中科院分区：
文献类型：
--
作者：
Goto, Rie;Mascie-Taylor, C. G. Nicholas;Lunn, Peter G.
为了测试贾第虫和土源性蠕虫感染对孟加拉国婴儿生长迟缓的影响，在位于达卡西北40公里的农村社区进行了为期36周的随机双盲安慰剂对照干预。年龄在3到15个月之间的婴儿被随机分配到抗贾第虫和驱虫治疗组、仅抗贾第虫治疗组或对照组。每4周记录一次体重和仰卧位长度。每12周检测肠道通透性（乳果糖/甘露醇比值）、血红蛋白、血浆白蛋白、α 1-酸性糖蛋白、IgG和贾第鞭毛虫特异性IgM（GSIGM）以及3种常见土源蠕虫和贾第鞭毛虫虫卵。确定囊肿。对222名完全依从的婴儿的数据进行了分析。干预组之间的肠道通透性、生化或人体测量变量无显著差异，尽管小肠粘膜功能改善与更好的体重饲料和身高体重（长度）Z评分之间存在关联。GSIgM滴度表明婴儿中贾第鞭毛虫快速再感染的地方病性很高;整个研究过程中，超过95%的婴儿呈阳性，而粪便检查显示极少数婴儿带有土蠕虫卵或贾第鞭毛虫囊肿（ClinicalTrials.gov标识符：NCT 00607074）。(C)2008年皇家热带医学和卫生学会。由爱思唯尔有限公司出版。保留所有权利。
In order to test the impact of Giardia and geohelminthic infection on infant growth faltering in Bangladesh, a randomised double-blind placebo controlled intervention of 36 weeks' duration was conducted in a rural community located 40 km northwest of Dhaka. Infants aged between 3 and 15 months were randomly assigned to either anti-Giardia and anthelminthic treatment, anti-Giardia treatment only, or a control. Weight and supine length were recorded every 4 weeks. Every 12 weeks intestinal permeability (lactulose/mannitol ratio), haemoglobin, plasma albumin, alpha-1-acid glycoprotein, IgG and Giardia-specific IgM (GSIgM) and eggs of the three common geohelminths and G. intestinalis cysts were determined. Data on 222 fully compliant infants were analysed. No significant differences in intestinal permeability, biochemical or anthropometric variables were found between the intervention groups, although there were associations between improvement in small intestinal mucosal function and better weight-forage and weight-for-height (length) Z-scores. GSIgM titres indicated high endemicity with rapid re-infection of Giardia among infants; over 95% of infants were positive throughout the study, whereas the stool examination showed very few infants with either geohelminth eggs or Giardia cysts (ClinicalTrials.gov Identifier: NCT00607074). (C) 2008 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.