A multi-layered vascular scaffold with symmetrical structure by bi-directional gradient electrospinning
A multi-layered vascular scaffold with symmetrical structure by bi-directional gradient electrospinning
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双向梯度静电纺丝对称结构多层血管支架
DOI：
10.1016/j.colsurfb.2015.05.048
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发表时间：
2015-09-01
影响因子：
5.8
通讯作者：
Mo, Xiumei
中科院分区：
文献类型：
--
作者：
Wu, Tong;Huang, Chen;Mo, Xiumei
多层支架具有良好的生物力学性能、生物相容性和生物可降解性，是血管组织工程的理想支架材料。本研究采用双向梯度静电纺丝法制备了聚（L-丙交酯-己内酯）（P（LLA-CL））、胶原蛋白和壳聚糖为基质的多层对称结构管状支架。与使用相同比例的原材料的混合支架相比，多层复合支架显示出更好的机械性能和生物相容性。由于纯天然材料制成的生物活性表面，多层支架上的内皮化加速。hSMCs的生长表现出类似的结果，因为其具有更好的生物相容性。纤维形态变化、pH值平衡和长期机械支撑结果表明，梯度结构有效地改善了生物降解性。(C)2015 Elsevier B. V.版权所有。
Multi-layered scaffolds are advantageous in vascular tissue engineering, in consideration of better combination of biomechanics, biocompatibility and biodegradability than the scaffolds with single structure. In this study, a bi-directional gradient electrospinning method was developed to fabricate poly(L-lactide-co-caprolactone) (P(LLA-CL)), collagen and chitosan based tubular scaffold with multi-layered symmetrical structure. The multi-layered composite scaffold showed improved mechanical property and biocompatibility, in comparison to the blended scaffold using the same proportion of raw materials. Endothelialization on the multi-layered scaffold was accelerated owing to the bioactive surface made of pure natural materials. hSMCs growth showed the similar results because of its better biocompatibility. Additionally, fibers morphology change, pH value balance and long term mechanical support results showed that the gradient structure effectively improved biodegradability. (C) 2015 Elsevier B.V. All rights reserved.