Epigenetic Regulation of Fatty Acid Amide Hydrolase in Alzheimer Disease
Epigenetic Regulation of Fatty Acid Amide Hydrolase in Alzheimer Disease
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DOI：
10.1371/journal.pone.0039186
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发表时间：
2012-06-12
期刊：
影响因子：
3.7
通讯作者：
Maccarrone, Mauro
中科院分区：
文献类型：
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作者：
D'Addario, Claudio;Di Francesco, Andrea;Maccarrone, Mauro
目的：阿尔茨海默病（AD）是一种进行性、退行性和不可逆的神经系统疾病，可用的治疗方法很少。在寻找新的潜在靶标时，越来越多的证据表明内源性大麻素系统 (ECS) 在调节神经退行性过程中发挥作用。方法：我们研究了晚发性 AD (LOAD) 受试者和年龄匹配对照 (CT) 受试者外周血单核细胞 (PBMC) 中 ECS 成分的基因表达状态和表观遗传调控。结果：我们发现 LOAD 受试者中脂肪酸酰胺水解酶 (faah) 基因表达增加 (2.30 +/- 0.48) 与 CT 相比 (1.00 +/- 0.14; *p
Objective: Alzheimer disease (AD) is a progressive, degenerative and irreversible neurological disorder with few therapies available. In search for new potential targets, increasing evidence suggests a role for the endocannabinoid system (ECS) in the regulation of neurodegenerative processes.Methods: We have studied the gene expression status and the epigenetic regulation of ECS components in peripheral blood mononuclear cells (PBMCs) of subjects with late-onset AD (LOAD) and age-matched controls (CT).Results: We found an increase in fatty acid amide hydrolase (faah) gene expression in LOAD subjects (2.30 +/- 0.48) when compared to CT (1.00 +/- 0.14; *p