NUCLEAR-MAGNETIC-RESONANCE STUDIES OF THE SOLUTION CHEMISTRY OF METAL-COMPLEXES .23. COMPLEXATION OF METHYLMERCURY BY SELENOHYDRYL-CONTAINING AMINO-ACIDS AND RELATED MOLECULES
NUCLEAR-MAGNETIC-RESONANCE STUDIES OF THE SOLUTION CHEMISTRY OF METAL-COMPLEXES .23. COMPLEXATION OF METHYLMERCURY BY SELENOHYDRYL-CONTAINING AMINO-ACIDS AND RELATED MOLECULES
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DOI：
10.1021/ic00234a030
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发表时间：
1986-07-02
影响因子：
4.6
通讯作者：
RABENSTEIN, DL
中科院分区：
文献类型：
--
作者：
ARNOLD, AP;TAN, KS;RABENSTEIN, DL
Introduction Since the outbreak of Minimata disease in Japan in the 1950s, there has been widespread interest in the biological chemistry of methylmercury (II)(CH3Hg11). CH3Hgn has such a high affinity for sulfur that it is assumed to be all complexed by thiol groups of amino acids, peptides, and proteins in vivo. 1-3 Direct experimental evidence for thiol complexation has been obtained from NMR studies of CH3Hgn-containing intact human erythro-cytes. 4 These* H NMR studies also show that, despite the large formation constants of the CH3HgIL-thiol complexes, 3· 5" 7 CH3Hgn exchanges rapidly among thiol ligands in intact cells. 4· 7" 9An intriguing aspect of CH3Hgn toxicology is that various selenium-containing compounds have significant protective effects in animal studies of CH3Hgn poisoning. 10· 11 The molecular basis for this effect has not yet been established; however, it is possible that it involves complexation of CH3Hgn by selenium donor
