Pituitary Adenylate Cyclase-Activating Polypeptide: A Promising Neuroprotective Peptide in Stroke.
Pituitary Adenylate Cyclase-Activating Polypeptide: A Promising Neuroprotective Peptide in Stroke.
复制标题
垂体腺苷酸环化酶激活多肽：一种有前途的中风神经保护肽
DOI：
10.14336/ad.2020.0626
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发表时间：
2020-12
影响因子：
7.4
通讯作者：
Zhang JH
中科院分区：
文献类型：
--
作者：
Fang Y;Ren R;Shi H;Huang L;Lenahan C;Lu Q;Tang L;Huang Y;Tang J;Zhang J;Zhang JH
由于急性脑卒中的高死亡率和发病率，寻找可行的、有效的治疗方法仍然是全球的优先事项。目前的治疗方法效果有限，因此寻找新的治疗方法势在必行。垂体腺苷酸环化酶激活多肽（Pituitary adenylate cyclase-activating polypeptide， PACAP）是一种公认的细胞保护神经肽，参与多种神经生理和病理活动，如神经元的增殖、分化和迁移，以及神经保护。它被认为是一种很有前途的治疗许多神经系统疾病的方法。因此，PACAP作为一种新的脑卒中治疗策略具有潜力。在此，我们概述了目前关于PACAP的知识，它的受体，它在中风背景下的潜在神经保护作用，以及各种神经保护机制，包括离子稳态、兴奋毒性、细胞水肿、氧化应激、炎症和细胞死亡，以及PACAP的给药途径。
The search for viable, effective treatments for acute stroke continues to be a global priority due to the high mortality and morbidity. Current therapeutic treatments have limited effects, making the search for new treatments imperative. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a well-established cytoprotective neuropeptide that participates in diverse neural physiological and pathological activities, such as neuronal proliferation, differentiation, and migration, as well as neuroprotection. It is considered a promising treatment in numerous neurological diseases. Thus, PACAP bears potential as a new therapeutic strategy for stroke treatment. Herein, we provide an overview pertaining to the current knowledge of PACAP, its receptors, and its potential neuroprotective role in the setting of stroke, as well as various mechanisms of neuroprotection involving ionic homeostasis, excitotoxicity, cell edema, oxidative stress, inflammation, and cell death, as well as the route of PACAP administration.
影响因子：
--
作者：
Sanchez, Alma;Rao, Haripriya Vittal;Grammas, Paula
通讯作者：
Grammas, Paula
影响因子：
2.9
作者：
Lenti L;Zimmermann A;Kis D;Oláh O;Tóth GK;Hegyi O;Busija DW;Bari F;Domoki F
通讯作者：
Domoki F