POLYMETHYLATED γ-CARBOLINES WITH POTENT ANTI-BOVINE VIRAL DIARRHEA VIRUS (BVDV) ACTIVITY
POLYMETHYLATED γ-CARBOLINES WITH POTENT ANTI-BOVINE VIRAL DIARRHEA VIRUS (BVDV) ACTIVITY
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DOI：
10.3987/com-08-s(f)68
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发表时间：
2009-02-01
期刊：
影响因子：
0.6
通讯作者：
Hashimoto, Yuichi
中科院分区：
文献类型：
--
作者：
Aoyama, Hiroshi;Sako, Kumiko;Hashimoto, Yuichi
合成了几种具有多甲基化γ-咔啉骨架的抗BVDV药物，并评估了它们的抗BVDV活性。最有效的抗病毒剂 SK3M4M5M (20) 是通过 Pd 催化的 Buchwald-Hartwig 胺化反应和随后的成环反应作为关键步骤合成的。分析了构效关系。
Several anti-BVDV agents with a polymethylated gamma-carboline skeleton were synthesized, and their anti-BVDV activity was evaluated. The most potent antiviral agent, SK3M4M5M (20), was synthesized by Pd-catalyzed Buchwald-Hartwig amination reaction followed by annulation reaction as key steps. The structure-activity relationship was analyzed.