Antileishmanial cyclic peroxides from the Palauan sponge Plakortis aff. angulospiculatus
Antileishmanial cyclic peroxides from the Palauan sponge Plakortis aff. angulospiculatus
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DOI：
10.1016/s0040-4020(98)00055-6
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发表时间：
1998-03-26
期刊：
影响因子：
2.1
通讯作者：
Faulkner, DJ
中科院分区：
文献类型：
--
作者：
Compagnone, RS;Piña, IC;Faulkner, DJ
作为发现治疗热带疾病新药的计划的一部分，我们从帕劳海绵Plakortis aff中分离和鉴定了六种新的代谢物。钩端螺旋体。两种环状过氧化物在体外对墨西哥利什曼原虫的前鞭毛体有很强的抑制增殖作用，利什曼原虫是一种引起利什曼病的鞭毛原虫。通过对光谱数据的解释、分子模拟和化学转化，确定了环状过氧化物1、2和5以及呋喃3、4和6的结构。(C)1998爱思唯尔科学有限公司。保留所有权利。
As part of a program to discover new drugs for the treatment of tropical diseases, we have isolated and identified six new metabolites from the Palauan sponge Plakortis aff. angulospiculatus. Two cyclic peroxides show strong in vitro antiproliferative effects on promastigotes of Leishmania mexicana, a flagellate protozoan that causes leishmaniasis. The structures of the cyclic peroxides 1, 2 and 5 and furans 3, 4 and 6 were elucidated by interpretation of spectroscopic data, molecular modelling, and chemical interconversions. (C) 1998 Elsevier Science Ltd. All rights reserved.