Performance evaluation of three rapid screening assays for detection of antibodies to hepatitis C virus in Cameroon.
Performance evaluation of three rapid screening assays for detection of antibodies to hepatitis C virus in Cameroon.
复制标题
DOI：
10.1186/s13104-018-3465-8
复制
发表时间：
2018-06-05
影响因子：
1.8
通讯作者：
Njouom, Richard
中科院分区：
文献类型：
--
作者：
Fondjo, Clavel Landry Kouam;Ngoupo, Paul Alain Tagnouokam;Njouom, Richard
目的：本研究的目的是评价三种CE认证的快速诊断试剂（RDT）：Multisure-HCV，First Response和Toyo;用于使用血浆样本筛查抗- HCV抗体的性能。这些RDT的敏感性和特异性分别为71 - 99%和78 - 100%。Multisure的灵敏度评分为99%（95% CI 97-100%），首次响应的特异性评分为90%（95% CI 85-94.9%）。应进行进一步研究，以建立一个算法，使用这些RTD检测丙型肝炎病毒感染在喀麦隆。
OBJECTIVE: This study was aimed at evaluating the performance of three CE-marked rapid diagnostic tests (RDTs): Multisure-HCV, First Response and Toyo; for screening anti- HCV antibody using plasma samples.RESULTS: Overall, 200 plasma samples were used. Sensibility and specificity of these RDTs range from 71 to 99 and 78 to 100% respectively. Multisure scored a sensitivity at 99% (95% CI 97-100%) and First Response reached a specificity at 90% (95% CI 85-94.9%). Further studies should be conducted to establish an algorithm using these RTDs for the detection of HCV infection in Cameroon.