Incongruent expression profiles between human and mouse orthologous genes suggest widespread neutral evolution of transcription control
Incongruent expression profiles between human and mouse orthologous genes suggest widespread neutral evolution of transcription control
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DOI：
10.1089/153623104773547462
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发表时间：
2004-03-01
影响因子：
3.3
通讯作者：
Ophir, R
中科院分区：
文献类型：
--
作者：
Yanai, I;Graur, D;Ophir, R
快速的进化速度可能意味着缺乏选择性约束，从而导致中性等位基因的积累，也可能意味着积极的达尔文选择驱动了优势等位基因的固定。基于对来自人类和小鼠的1，350个直向同源基因对的比较，我们表明基因表达谱的进化是如此之快，以至于可以与旁系同源基因对或随机配对的基因相媲美。在整组的正交序列对中的表达差异既不与序列差异强烈相关，也不集中在任何特定组织中。此外，通过比较正交基因对的组织表达，我们观察到任何人类组织与所检查的任何其他人类组织比其相应的小鼠组织更相似。总的来说，这些结果表明，虽然表达谱的一些差异可能是由于适应性进化，分歧的水平大多是兼容的中性模式的进化，其中异位表达的突变可能会上升到固定的随机漂移，而不会显着影响健身。这些发现的一个令人不安的推论是，关于基因表达位置的知识可能并不包含有关其功能的信息。
Rapid rates of evolution can signify either a lack of selective constraint and the consequent accumulation of neutral alleles, or positive Darwinian selection driving the fixation of advantageous alleles. Based on a comparison of 1,350 orthologous gene pairs from human and mouse, we show that the evolution of gene expression profiles is so rapid that it is comparable to that of paralogous gene pairs or randomly paired genes. The expression divergence in the entire set of orthologous pairs neither strongly correlates with sequence divergence, nor focuses in any particular tissue. Moreover, comparing tissue expressions across the orthologous gene pairs, we observe that any human tissue is more similar to any other human tissue examined than to its corresponding mouse tissue. Collectively, these results indicate that, while some differences in expression profiles may be due to adaptive evolution, the levels of divergence are mostly compatible with a neutral mode of evolution, in which a mutation for ectopic expression may rise to fixation by random drift without significantly affecting the fitness. A disturbing corollary of these findings is that knowledge of where the gene is expressed may not carry information about its function.