Proton Magnetic Resonance Spectroscopy Reveals Medial Temporal Metabolic Abnormalities in Adolescents With History of Preterm Birth
Proton Magnetic Resonance Spectroscopy Reveals Medial Temporal Metabolic Abnormalities in Adolescents With History of Preterm Birth
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DOI：
10.1203/pdr.0b013e3181841eab
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发表时间：
2008-11-01
影响因子：
3.6
通讯作者：
Mercader, Josep Maria
中科院分区：
文献类型：
--
作者：
Gimenez, Monica;Soria-Pastor, Sara;Mercader, Josep Maria
早产与特定大脑区域（如海马体）的体积减少以及可通过光谱检测到的代谢变化有关。采用短回波时间（135 ms）质子磁共振波谱（H-1 MRS）评估21例早产青少年（平均年龄：14.8岁）可能的内侧颞叶代谢异常。SD: 1.3)，与年龄匹配的对照样本（平均年龄：14.8）相比。SD: 1.6)。用线性组合模型拟合H-1 MRS光谱，得到克汀（Cr）和肌醇（Ins）的绝对代谢物浓度。此外，还测定了以下代谢物的数量：总Cho （olycerophosphocholine + phosphocholine）。总n -乙酰-天冬氨酸+ n -乙酰-天冬氨酸谷氨酸（NA）和总谷氨酸（谷氨酸+谷氨酰胺）。通过体视学分析计算海马体积。早产儿组绝对Cr.和总NA值降低（p = 0.016; p = 0.002）。早产儿也显示海马减少（p < 0.0001）。孕周与不同代谢物和海马体积之间存在显著关系。此外。在整个样本中，海马体积与脑代谢物相关。结果表明，早产影响内侧颞叶代谢物。这种变化与结构变化有关，这表明大脑的变化会持续到青春期。(儿科杂志64:572-577。2008)
Prematurity is associated with volumetric reductions in specific brain areas such as the hippocampus and with metabolic changes that can be detected by spectroscopy. Short echo time (135 ms) Proton magnetic resonance spectroscopy (H-1 MRS) was performed to assess possible medial temporal lobe metabolic abnormalities in 21 adolescents with preterm birth (mean age: 14.8. SD: 1.3) compared with an age-matched control sample (mean age: 14.8. SD: 1.6). H-1 MRS spectra were analyzed with linear combination model fitting, obtaining the absolute metabolite concentrations for Cretaine (Cr), and myo-inositol (Ins). In addition, the following metabolite sums were measured: total Cho (olycerophospho-choline + phosphocholine). total N-acetyl-aspartate + N-acetyl-aspartylglutamate (NA), and total Glx (glutamate + glutamine). A stereological analysis was performed to calculate hippocampal volume. Absolute Cr. and total NA values were decreased in the preterm group(p = 0.016; p = 0.002 respectively). The preterm also showed a hippocampal reduction (p < 0.0001). Significant relationships were found between gestational age and different metabolites and the hippocampal Volume. Moreover. hippocampal volume correlated with brain metabolites in the whole sample. Results demonstrate that prematurity affects medial temporal lobe metabolites. and that the alteration is related to Structural Changes, suggesting that (lie cerebral changes persist until adolescence. (Pediatr Res 64: 572-577. 2008)