Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults
Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults
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DOI：
10.2337/dc07-1338
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发表时间：
2008-02-01
期刊：
影响因子：
16.2
通讯作者：
Goldfine, Allison B.
中科院分区：
文献类型：
--
作者：
Fleischman, Amy;Shoelson, Steven E.;Goldfine, Allison B.
目的 - 久坐的生活方式和西方饮食会促进亚急性 - 慢性炎症、肥胖以及随后的血糖异常。本研究的目的是评估抗炎药物双水杨酯通过减轻有2型糖尿病发病风险的肥胖成年人的全身炎症来改善血糖的功效。
研究设计与方法 - 在一项双盲、安慰剂对照试验中，我们在基线时以及双水杨酯或安慰剂治疗1个月后对20名肥胖的非糖尿病成年人进行了评估。
结果 - 与安慰剂相比，双水杨酯使空腹血糖降低13%（P < 0.002），口服葡萄糖耐量试验后的血糖反应降低20%（P < 0.004），糖化白蛋白降低1.7%（P < 0.0003）。尽管胰岛素水平未改变，但与安慰剂相比，双水杨酯治疗的受试者空腹和口服葡萄糖耐量试验C肽水平降低（P < 0.03），这与胰岛素敏感性改善以及已知的水杨酸盐抑制胰岛素清除的作用一致。与安慰剂相比，双水杨酯治疗后脂联素增加57%（P < 0.003）。此外，在双水杨酯治疗组中，C反应蛋白的循环水平降低了34%（P < 0.05）。
结论 - 这项原理验证研究表明，双水杨酯可降低血糖，并可能改善超重个体的炎症性心血管风险指标。这些数据支持亚急性 - 慢性炎症促成肥胖相关血糖异常的发病机制这一假设，并且针对炎症可能为糖尿病预防提供一种治疗途径。
OBJECTIVE - Sedentary lifestyle and a western diet promote subacute-chronic inflammation, obesity, and subsequently dysglycemia. The aim of the current study was to evaluate the efficacy of the anti-inflammatory drug salsalate to improve glycemia by reducing systemic inflammation in obese adults at risk for the development of type 2 diabetes.RESEARCH DESIGN AND METHODS - in a double-masked, placebo controlled trial, we evaluated 20 obese nondiabetic adults at baseline and after 1 month of salsalate or placebo.RESULTS - Compared with placebo, salsalate reduced fasting glucose 13% (P < 0.002), glycemic response after an oral glucose challenge 20% (P < 0.004), and glycated albumin 1.7% (P < 0.0003). Although insulin levels were Unchanged, fasting and oral glucose tolerance test C-peptide levels decreased in the salsalate-treated subjects compared with placebo (P < 0.03), consistent with improved insulin sensitivity and a known effect Of Salicylates to inhibit insulin clearance. Adiponectin increased 57% after salsalate compared With placebo (P < 0.003). Additionally, within the group of salsalate-treated subjects, circulating levels of C-reactive protein were reduced by 34% (P < 0.05).CONCLUSIONS - This proof-of-principle study demonstrates that salsalate reduces glycemia and may improve inflammatory cardiovascular risk indexes in overweight individuals. These data support the hypothesis that subacute-chronic inflammation contributes to the pathogenesis of obesity-related dysglycemia and that targeting inflammation may provide a therapeutic route for diabetes prevention.