Activation of RIG-I-like receptor signal transduction.
Activation of RIG-I-like receptor signal transduction.
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DOI：
10.3109/10409238.2011.630974
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发表时间：
2012-03
影响因子：
6.5
通讯作者：
Horvath CM
中科院分区：
文献类型：
--
作者：
Bruns AM;Horvath CM
哺乳动物细胞具有识别病毒感染并产生强大抗病毒反应的能力。模式识别受体蛋白检测病毒感染的分子特征并激活抗病毒信号级联反应。rig - i样受体是细胞质DExD/H盒蛋白，可以特异性识别病毒衍生的RNA物种，作为区分病原体和宿主的分子特征。RIG-I样受体家族由RIG-I、MDA5和LGP2三个同源蛋白组成。所有这些蛋白都可以通过其保守的DExD/H盒RNA解旋酶结构域和c端调控结构域结合具有不同亲和力的双链RNA物种。RLRs对外源RNA的识别激活酶功能，启动信号转导通路，导致抗病毒细胞因子的产生，并建立广泛有效的细胞抗病毒状态，保护邻近细胞免受感染，触发先天和适应性免疫系统。该信号通过干扰素抗病毒系统的传播已被广泛研究，而RNA解旋酶结构域的酶活性在抗病毒反应中的确切作用才刚刚开始阐明。本文综述了RLR配体识别和信号转导的现有模型。
Mammalian cells have the ability to recognize virus infection and mount a powerful antiviral response. Pattern recognition receptor proteins detect molecular signatures of virus infection and activate antiviral signaling cascades. The RIG-I-like receptors are cytoplasmic DExD/H box proteins that can specifically recognize virus-derived RNA species as a molecular feature discriminating the pathogen from the host. The RIG-I-like receptor family is composed of three homologous proteins, RIG-I, MDA5, and LGP2. All of these proteins can bind double-stranded RNA species with varying affinities via their conserved DExD/H box RNA helicase domains and C-terminal regulatory domains. The recognition of foreign RNA by the RLRs activates enzymatic functions and initiates signal transduction pathways resulting in the production of antiviral cytokines and the establishment of a broadly effective cellular antiviral state that protects neighboring cells from infection and triggers innate and adaptive immune systems. The propagation of this signal via the interferon antiviral system has been studied extensively, while the precise roles for enzymatic activities of the RNA helicase domain in antiviral responses are only beginning to be elucidated. Here, current models for RLR ligand recognition and signaling are reviewed.
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影响因子：
56.9
作者：
Choudhary, Chunaram;Kumar, Chanchal;Mann, Matthias
通讯作者：
Mann, Matthias
影响因子：
3.7
作者：
Gao D;Yang YK;Wang RP;Zhou X;Diao FC;Li MD;Zhai ZH;Jiang ZF;Chen DY
通讯作者：
Chen DY
影响因子：
7.7
作者：
Friedman, Constantin S.;O'Donnell, Marie Anne;Ting, Adrian T.
通讯作者：
Ting, Adrian T.
影响因子：
4.8
作者：
Bamming, Darja;Horvath, Curt M.
通讯作者：
Horvath, Curt M.
二羟基丙酮激酶对 MDA5 而非 RIG-I 介导的先天抗病毒信号进行负调节
DOI：
10.1073/pnas.0700544104
发表时间：
2007-07-10
影响因子：
11.1
作者：
Diao, Feici;Li, Shu;Shu, Hong-Bing
通讯作者：
Shu, Hong-Bing