MicroRNA in the Diseased Pulmonary Vasculature: Implications for the Basic Scientist and Clinician.
MicroRNA in the Diseased Pulmonary Vasculature: Implications for the Basic Scientist and Clinician.
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DOI：
10.5646/jksh.2013.19.1.1
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Chan SY
中科院分区：
文献类型：
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作者：
Jin RC;Min PK;Chan SY
自十多年前首次描述其活性功能以来，称为microRNA（miRNA）的小的非编码RNA种类已经成为广泛的适应性和适应不良细胞过程中的重要调节因子。随着这一领域的发现速度异常快，许多个体miRNA的失调与各种心血管疾病的发生和进展有关。miRNA还有望在肺血管疾病如肺动脉高压（PH）的进展中发挥关键的调节作用，但在这一领域的直接见解才刚刚出现。本综述将提供肺动脉高压及其分子机制的概述，为研究肺血管生物学的基础科学家和在临床实践中管理PH的医生量身定制。我们将描述肺动脉高压的病理生物学和与这种疾病相关的miRNA的作用机制。此外，我们还将总结miRNA作为生物标志物和治疗靶点的潜在作用，以及未来确定这些强大效应物在肺血管疾病中的协同作用的策略。
Since the first descriptions of their active functions more than ten years ago, small non-coding RNA species termed microRNA (miRNA) have emerged as essential regulators in a broad range of adaptive and maladaptive cellular processes. With an exceptionally rapid pace of discovery in this field, the dysregulation of many individual miRNAs has been implicated in the development and progression of various cardiovascular diseases. MiRNA are also expected to play crucial regulatory roles in the progression of pulmonary vascular diseases such as pulmonary hypertension (PH), yet direct insights in this field are only just emerging. This review will provide an overview of pulmonary hypertension and its molecular mechanisms, tailored for both basic scientists studying pulmonary vascular biology and physicians who manage PH in their clinical practice. We will describe the pathobiology of pulmonary hypertension and mechanisms of action of miRNA relevant to this disease. Moreover, we will summarize the potential roles of miRNA as biomarkers and therapeutic targets as well as future strategies for defining the cooperative actions of these powerful effectors in pulmonary vascular disease.