The molecular biology of SRY and its role in sex determination in mammals

The molecular biology of SRY and its role in sex determination in mammals
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DOI:
10.1071/rd9950713
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发表时间:
1995-01-01
影响因子:
1.9
通讯作者:
Koopman, P
Koopman, P
中科院分区:
生物学4区
文献类型:
--
作者:
Koopman, P

文献摘要

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SRY is the gene that initiates the genetic cascade leading to testis development in mammals. Since its discovery in 1990 and the direct demonstration of its male-determining role in transgenic mice, attention has turned to understanding the biochemical mode of action of the SRY gene product, and to the identification of other genes in the sex-determining pathway. Recent progress in these efforts is summarized in this review.