Gold@mesoporous polydopamine nanoparticles modified self-healing hydrogel for sport-injuring therapy.
Gold@mesoporous polydopamine nanoparticles modified self-healing hydrogel for sport-injuring therapy.
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DOI：
10.1016/j.ijbiomac.2023.127441
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发表时间：
2023-10
影响因子：
8.2
通讯作者：
Yu Zhou;Baoyong Xu;Pan Zhou;Xiaohui Chen;Genlong Jiao;Hong Li
中科院分区：
文献类型：
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作者：
Yu Zhou;Baoyong Xu;Pan Zhou;Xiaohui Chen;Genlong Jiao;Hong Li
Sports-related damage is a prevalent issue, which a combination therapy including photothermal irradiation, self-healing dressing and antibacterial treatment is an effective way to rehabilitate it. In the study, a multifunctional hydrogel was developed to meet the requirement. Firstly, mesoporous polydopamine (MPDA) was prepared, where gold nanoparticles (Au NPs) were formed in its mesoporous structure, to construct Au@MPDA NPs with nanosize about 200 nm. Synergetic and efficient photothermal effect was achieved by the combination of the two photothermal agents. The Au@MPDA NPs were then added to modify polyvinyl alcohol-carboxymethyl chitosan-borax (PCB) hydrogel.Viarheological property characterization, cell experiments and antibacterial evaluation, high photothermal efficiency and effective antibacterial activity of Au@MPDA@PCB hydrogel was obtained with the aid of Au@MPDA NPs, together with self-healing property. When treated in motion-related tissue, the modified hydrogel showed excellent adaptive property and photothermal effectin situ. This study is beneficial for developing a novel rehabilitation treatment strategy for sports-related injuries.
