Different neurons in different regions of human temporal lobe distinguish correct from incorrect identification or memory.
Different neurons in different regions of human temporal lobe distinguish correct from incorrect identification or memory.
复制标题
人类颞叶不同区域的不同神经元区分正确和错误的识别或记忆。
DOI：
10.1016/j.neuropsychologia.2004.01.008
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发表时间：
2004
期刊：
影响因子：
2.6
通讯作者：
Corina,David
中科院分区：
文献类型：
--
作者：
Ojemann,GeorgeA;Schoenfield-McNeill,Julie;Corina,David
对26例接受清醒神经外科手术的患者，在识别和最近的外显记忆过程中，在颞叶62个部位的113个神经元的细胞外记录中，识别正确反应和错误反应的神经活动频率的变化。在12名患者的16个部位的22个神经元中发现了显著区分正确和不正确表现的活动。不同区域的不同神经元区分识别或记忆性能。其中13个神经元在内侧-基底回表现出较高的辨别能力，9个神经元在上级颞回表现出较高的辨别记忆能力。所有内存更改都发生在编码期间。对于识别和记忆有分离的神经元显示分化早期在感知和处理从那些显示分化晚，当输出应该发生，也许反映了反应监测。早期分化的神经元位于更上外侧的不同区域内的识别或记忆的准确性。
Changes in the frequency of neural activity differentiating correct from incorrect responses were identified in extracellular recordings from 113 neurons at 62 sites in temporal lobe of 26 patients undergoing awake neurosurgery, during identification and recent explicit memory for object names, text or auditory words. Activity significantly differentiating correct from incorrect performance was identified in 22 neurons at 16 sites in 12 patients. Different neurons in different regions differentiated identification or memory performance. The 13 neurons differentiating identification performance were overrepresented in medial-basal recordings, the 9 neurons differentiating memory performance in superior temporal gyrus. All memory changes occurred during encoding. For both identification and memory there was separation of neurons showing differentiation early during perception and processing from those showing differentiation late, when output should occur, perhaps reflecting response monitoring. Early differentiating neurons were located more superior-laterally within the different regions related to accuracy of identification or memory.