A comparison of osteoclast resorption pits on bone with titanium and zirconia surfaces
A comparison of osteoclast resorption pits on bone with titanium and zirconia surfaces
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DOI：
10.1016/j.biomaterials.2010.06.009
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发表时间：
2010-10-01
期刊：
影响因子：
14
通讯作者：
Schlottig, Falko
中科院分区：
文献类型：
--
作者：
Hefti, Thomas;Frischherz, Martina;Schlottig, Falko
破骨细胞吸收表面的骨头，在骨头的矿物质和有机相溶解的地方留下凹坑和痕迹。粗糙的表面结构被有意地赋予合成种植体，以改善骨整合。本研究的目的是表征原生骨表面的破骨细胞吸收坑，并将其与最先进的钛和氧化锆种植体表面进行比较。将吸收坑的大小（即长度、宽度和深度）与喷砂和蚀刻钛和氧化锆表面特征的大小进行比较。发现原生骨的吸收坑与喷砂和蚀刻的钛和氧化锆表面特征在尺寸上非常相似。大多数结构的长度在5 - 40 μ m之间，宽度在2 - 20 μ m之间，深度在1 - 8 μ m之间。此外，测量了波长相关的表面粗糙度，显示吸收坑的S-a值为60 nm，氧化锆表面为86 nm，钛表面为127 - 140 nm。本研究的结果可能为骨重塑周期的结构要求提供一些见解，并有助于改进用于骨整合应用的新型种植体表面的设计。(C) 2010 Elsevier Ltd.版权所有。
Osteoclasts resorb bone at surfaces, leaving behind pits and trails where both mineral and organic phases of bone have been dissolved. Rough surface structures are deliberately imparted to synthetic implants, in order to improve osseointegration. The aim of this study is to characterize osteoclastic resorption pits on native bone surfaces and to compare these with state-of-the-art titanium and zirconia implant surfaces. The size (i.e. length, width and depth) of resorption pits was compared to the size of surface features of sandblasted and etched titanium and zirconia surfaces. It was found that resorption pits from native bone and surface features of the sandblasted and etched titanium and zirconia surfaces were quite similar in their dimensions. Most structures showed a length between 5 and 40 mu m, a width between 2 and 20 pm and a depth between 1 and 8 mu m. Additionally, the wavelength-dependent surface roughness was measured, revealing an S-a value of 60 nm in the resorption pits, 86 nm on zirconia and between 127 and 140 nm on titanium surfaces. The results of this study may provide some insight into structural requirements for the bone-remodeling cycle and help to improve the design of new implant surfaces for osseointegration applications. (C) 2010 Elsevier Ltd. All rights reserved.