Activation of intrinsic laryngeal muscles during cough.
Activation of intrinsic laryngeal muscles during cough.
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咳嗽时激活喉内肌。
DOI：
10.1164/ajrccm.155.2.9032206
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Sant'Ambrogio,FB
中科院分区：
文献类型：
--
作者：
Sant'Ambrogio,G;Kuna,ST;Vanoye,CR;Sant'Ambrogio,FB
我们研究了12只麻醉犬咳嗽时环杓后肌（PCA）、环甲肌（CT）、甲状腺杓状肌（TA）和环杓横肌（AR）的放电模式。同时记录膈肌电图（EMG）活动、声门下压和食管压。机械刺激气管支气管引起连续的反复咳嗽。在双侧喉上神经（SLN）内支切断术前后分别进行了上气道与下气道分离并连接的试验。气管刺激的直接效果是FRC的“呼吸暂停”期，在此期间，喉外展肌PCA的活动逐渐增加，同时CT和喉内收肌TA和AR的活动略有变化。随后的咳嗽努力分为三个阶段：吸气、声门变窄和强迫呼气。PCA活性在吸气期最大，CT活性在呼气期最大。声门下压力峰值发生在声门变窄期间，与咳嗽时TA和AR的最大激活以及PCA和CT的抑制相吻合。肌电图的激活模式不受呼吸方式和SLN切片的影响。结果表明，存在一个独特的中央过程控制喉部肌肉咳嗽期间，独立于喉的感觉反馈。
We studied the pattern of discharge of the posterior cricoarytenoid (PCA), cricothyroid (CT), thyroarytenoid (TA), and arytenoideus transversus (AR) muscles during cough in 12 anesthetized dogs. Diaphragm electromyographic (EMG) activity was also recorded, together with subglottic and esophageal pressures. Trains of repetitive coughs were induced by mechanically stimulating the tracheobronchial airway. Trials with the upper airway isolated from and connected to the lower airway were performed before and following bilateral sectioning of the internal branch of the superior laryngeal nerve (SLN). The immediate effect of tracheal stimulation was an "apneic" period at FRC, during which the PCA, a laryngeal abductor, showed a progressive increase in activity accompanied by small, variable increases in the activity of the CT and the laryngeal adductors, the TA and AR. The subsequent cough efforts were divided into three phases: inspiration, glottic narrowing, and forced expiration. PCA activity was greatest during the inspiratory phase and CT activity was greatest during the expiratory phase. Peak subglottic pressure occurred during glottic narrowing and coincided with the greatest activation of the TA and AR during the cough effort, and suppression of the PCA and CT. The patterns of EMG activation were not affected by the route of breathing or SLN section. The results suggest the presence of a uniquely central process controlling laryngeal muscles during cough, independent of laryngeal sensory feedback.