Effect of SBD.4A--a defined multicomponent preparation of Angelica sinensis--in periodontal regeneration models.
Effect of SBD.4A--a defined multicomponent preparation of Angelica sinensis--in periodontal regeneration models.
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SBD.4A（一种确定的当归多组分制剂）在牙周再生模型中的作用。
DOI：
10.1002/ptr.2421
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Bojanowski,Krzysztof
中科院分区：
文献类型：
--
作者：
Zhao,Hui;Alexeev,Alexei;Sharma,Vrushali;Guzman,LorenzoDaveT;Bojanowski,Krzysztof
牙周炎是牙齿活动和丧失的主要原因，导致牙齿的支撑结构（包括牙周韧带和牙槽骨）的破坏。牙周手术可以减缓疾病的进展，但成本高，侵入性强，受禁忌症和技术敏感性的限制。最近，使用蛋白质生物制剂的非侵入性药物治疗已经成为可能。在这里，第一次，骨再生能力的非蛋白质生物-SBD. 4A-一种新的，稳定的多组分生长因子分离自药用植物当归报道。SBD. 4A在成骨细胞增殖和分化系统以及成纤维细胞分泌的透明质酸测定中进行了测试。此外，将SBD. 4A配制在缓释基质中，并在大鼠颅骨缺损模型中进行测试。除了先前报道的对血管生成、成纤维细胞生长和胶原蛋白合成的强烈刺激-牙周再生所需的活性-SBD. 4A增强了体外透明质酸的沉积和成骨细胞的增殖，以及大鼠颅骨缺损模型中的骨再生。总之，这些结果表明SBD. 4对牙周膜和骨再生的有益作用，为进一步开发这种植物生长因子提供了理由。版权所有© 2008约翰威利父子有限公司。
Periodontitis is a major cause of tooth motility and loss, resulting in destruction of the supporting structures of the tooth, including periodontal ligaments and alveolar bone. Periodontal surgery can slow the progression of the disease, but is costly, invasive, limited by contraindications and technique‐sensitive. Recently, non‐invasive pharmacological treatments using proteinaceous biologicals have become available. Here, for the first time, the bone‐regenerative capabilities of a non‐proteinaceous biological – SBD.4A – a novel, stable multicomponent growth factor isolated from a medicinal plantAngelica sinensisare reported. SBD.4A was tested in osteoblast proliferation and differentiation systems, as well as in a fibroblast‐secreted hyaluronic acid assay. Furthermore, SBD.4A was formulated in a slow release matrix and tested in the rat calvarial defect model. Apart from the previously reported strong stimulation of angiogenesis, fibroblast growth and collagen synthesis – the activities needed for periodontal regeneration – SBD.4A enhanced the deposition of hyaluronic acid and proliferation of osteoblastsin vitro, as well as bone regeneration in the rat calvarial defect model. Together, these results indicate the beneficial effect of SBD.4 on periodontal ligament and bone regeneration making the case for further development of this botanical growth factor. Copyright © 2008 John Wiley & Sons, Ltd.