Mathematical analysis of a mechanism for autonomous metabolic oscillations in continuous culture of Saccharomyces cerevisiae
Mathematical analysis of a mechanism for autonomous metabolic oscillations in continuous culture of Saccharomyces cerevisiae
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DOI：
10.1016/s0014-5793(01)02562-5
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发表时间：
2001-06-22
期刊：
影响因子：
3.5
通讯作者：
Kuriyama, H
中科院分区：
文献类型：
--
作者：
Wolf, J;Sohn, HY;Kuriyama, H
在酿酒酵母的有氧连续培养中观察到了自主代谢振荡。实验研究表明，该过程涉及多个途径和调控偶联。本文将硫酸盐同化途径、乙醇降解和呼吸作用等假设机制转化为数学模型。模拟证实了模型产生极限环振荡的能力，该振荡再现了系统的大部分特征，（C）2001年欧洲生物化学学会联合会。由Elsevier Science B.V.出版，版权所有。
Autonomous metabolic oscillations were observed in aerobic continuous culture of Saccharomyces cerevisiae. Experimental investigation of the underlying mechanism revealed that several pathways and regulatory couplings are involved, Here a hypothetical mechanism including the sulfate assimilation pathway, ethanol degradation and respiration is transformed into a mathematical model. Simulations confirm the ability of the model to produce limit cycle oscillations which reproduce most of the characteristic features of the system, (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.