HLA-D typing with homozygous cells identified in an American indigenous isolate. II. Family studies and D/DR relationship.
HLA-D typing with homozygous cells identified in an American indigenous isolate. II. Family studies and D/DR relationship.
复制标题
使用在美国本土分离株中鉴定出的纯合细胞进行 HLA-D 分型。
作者：
Z. Layrisse;H. Heinen;N. Simonney
12个美国印第安人核心家庭有2-5个兄弟姐妹，用混合淋巴细胞培养和高加索血统纯合分型细胞(HTC)检测DW1-DW7，用美洲印第安人血统分型细胞检测LD5A、LD15A和LD15B抗原，进行HLA-D分型。结果表明，在这些家系中完全不存在DW1-DW7，并说明了LD5A、LD15A和LD15B的遗传和分离。第8届国际组织相容性研讨会抗血清遗传组的DR分型结果表明，DR2与LD5A、DR6.2(DR3+6、MT1阴性、MT2阳性)与LD15A、DRW8与LD15B偶联遗传。推测该人群中存在不同于DW4但与DRW4相关的MLC激活抗原(S)。在这个美洲印第安人分离株中存在D/DR关系再次表明，DR2可以与不同于DW2的HLA-D抗原一起遗传，且LD15A HTC定义了广泛的DW6特异组的第二个亚群，该亚群在Warao人群中与DRW6.2和BW62抗原一起遗传。
Twelve American Indian nuclear families with 2-5 siblings have been HLA-D typed using mixed lymphocyte cultures and clusters of homozygous typing cells (HTC) of Caucasoid origin to detect DW1-DW7 and typing cells of American Indian origin to detect LD5A, LD15A and LD15B antigens. Results obtained demonstrate complete absence of DW1-DW7 in these families and illustrate the inheritance and segregation of LD5A, LD15A and LD15B. DR typing results obtained with the 8th International Histocompatibility Workshop genetic set of antisera indicate inheritance in coupling of DR2 with LD5A, of DR6.2 (DR3+6, MT1 negative, MT2 positive) with LD15A, and of DRW8 with LD15B. The existence of MLC activating antigen(s) different to DW4, yet associated to DRW4 in this population is postulated. The D/DR relationship present in this American Indian isolate demonstrate once more that DR2 can be inherited in combination with an HLA-D antigen different to DW2, and that LD15A HTC define a second sub-cluster of the broad DW6 specificity group, which is inherited with DRW6.2 and BW62 antigens in the Warao population.
美洲印第安人之谜。
影响因子：
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作者：
Kostyu,DD;Amos,DB
通讯作者：
Amos,DB