Potent inhibition of retinoic acid metabolism enzyme(s) by novel azolyl retinoids
Potent inhibition of retinoic acid metabolism enzyme(s) by novel azolyl retinoids
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DOI：
10.1016/s0960-894x(00)00391-7
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发表时间：
2000-09-04
影响因子：
2.7
通讯作者：
Brodie, AMH
中科院分区：
文献类型：
--
作者：
Njar, VCO;Nnane, IP;Brodie, AMH
Novel (+/-)-4-azolyl retinoic acid analogues 4, 5, 7 and 8 have been designed and synthesized and have been shown to be powerful inhibitors of hamster microsomal all-trans-retinoic acid 4-hydroxylase enzyme(s). (+/-)-4-(1H-Imidazol-1-yl)retinoic acid (4) is the most potent inhibitor of this enzyme reported to date. (C) 2000 Elsevier Science Ltd. All rights reserved.
