Coffee Intake and Risk of Hypertension: A Meta-Analysis of Cohort Studies.
Coffee Intake and Risk of Hypertension: A Meta-Analysis of Cohort Studies.
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DOI：
10.3346/jkms.2022.37.e332
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发表时间：
2022-11-21
影响因子：
4.5
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中科院分区：
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目前尚不清楚咖啡摄入量是否与高血压风险相关。本研究旨在通过队列研究的荟萃分析来调查咖啡摄入量与高血压风险之间的关联。 2022 年 9 月，使用关键词对 PubMed 和 Embase 进行了搜索，以确定有关咖啡摄入量和高血压风险的研究。我们总共纳入了 13 项纵向队列研究，涉及 314,827 名参与者中总共 64,650 例高血压病例。在所有研究的随机效应模型荟萃分析中，咖啡摄入量与高血压风险没有显着相关（相对风险 [RR]，0.97；95% 置信区间 [CI]，0.90–1.05；I2 = 58.0%；n = 13）。在亚组荟萃分析中，在美国进行的研究（RR，0.93；95% CI，0.87-0.98；I2 = 4.6%；n = 5）和低质量研究（RR，0.92；95% CI，0.88-0.96；I2 = 0.0%；n = 7）中，咖啡摄入量与高血压风险降低相关。在按咖啡摄入量、性别、咖啡类型（不含咖啡因与含咖啡因）、吸烟和随访年数进行的其余亚组荟萃分析中，咖啡摄入量与高血压风险没有显着相关。目前的荟萃分析表明，咖啡摄入量与高血压风险无关。
It remains unclear whether coffee intake is associated with the risk of hypertension. This study aimed to investigate the association between coffee intake and the risk of hypertension by using a meta-analysis of cohort studies. PubMed and Embase were searched using keywords in September 2022 to identify studies on coffee intake and the risk of hypertension. We included a total of 13 longitudinal cohort studies, which involved a total of 64,650 incident cases of hypertension among 314,827 participants. In a random effects model meta-analysis of all the studies, coffee intake was not significantly associated with the risk of hypertension (relative risk [RR], 0.97; 95% confidence interval [CI], 0.90–1.05; I2 = 58.0%; n = 13). In the subgroup meta-analysis, coffee intake was associated with a decreased risk of hypertension in studies conducted in America (RR, 0.93; 95% CI, 0.87–0.98; I2 = 4.6%; n = 5) and in low-quality studies (RR, 0.92; 95% CI, 0.88–0.96; I2 = 0.0%; n = 7). In the remaining subgroup meta-analyses by amount of coffee intake, gender, type of coffee (decaffeinated vs. caffeinated), smoking, and years of follow-up, coffee intake was not significantly associated with the risk of hypertension. The current meta-analysis showed that coffee intake is not associated with the risk of hypertension.