Klotho-related Molecules Upregulated by Smoking Habit in Apparently Healthy Men: A Cross-sectional Study.
Klotho-related Molecules Upregulated by Smoking Habit in Apparently Healthy Men: A Cross-sectional Study.
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DOI：
10.1038/srep14230
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发表时间：
2015-09-18
影响因子：
4.6
通讯作者：
Yamauchi-Takihara K
中科院分区：
文献类型：
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作者：
Nakanishi K;Nishida M;Harada M;Ohama T;Kawada N;Murakami M;Moriyama T;Yamauchi-Takihara K
虽然衰老是不可避免的，但由于其复杂性，衰老机制仍然不清楚。吸烟导致过早死亡，被认为是环境老化加速器。本研究旨在探讨吸烟对男性血清中抗衰老蛋白α-klotho（αKl）和β-klotho相关蛋白成纤维细胞生长因子（FGF）-21浓度的影响。受试者包括40岁以上的明显健康的男性，他们接受了健康检查。物理和生化参数，包括几种细胞因子和生长因子的水平，从受试者。在中年男性（46.1 ± 5.1岁）中，吸烟者的FGF-21、可溶性αKl（sαKl）和炎症相关细胞因子白细胞介素（IL）-6的血清水平显著高于从不吸烟者。仅在吸烟者中，FGF-21血清水平升高，并与丙氨酸转氨酶、γ-鸟苷-5 ′-三磷酸和总胆固醇相关，表明FGF-21是吸烟者中的代谢紊乱相关因子。在老年男性（60.3 ± 1.7岁）中，虽然不吸烟者血清sαKl水平较低，但吸烟者血清sαKl水平显著升高。在中年不吸烟者中，血清sαKl水平与IL-6水平相关，表明sαKl调节IL-6。然而，这种相关性在吸烟者和老年男性中被破坏。
While aging is unavoidable, the aging mechanism is still unclear because of its complexity. Smoking causes premature death and is considered as an environmental aging accelerator. In the present study, we focused on the influence of smoking to the serum concentration of anti-aging protein α-klotho (αKl) and the β-klotho-associated protein fibroblast growth factor (FGF)-21 in men. Subjects consisted of apparently healthy men over 40 years of age who underwent health examination. Physical and biochemical parameters, including the levels of several cytokines and growth factors, were obtained from the subjects. Among middle-aged men (46.1 ± 5.1 years), serum levels of FGF-21, soluble αKl (sαKl), and inflammation-related cytokine interleukin (IL)-6 were significantly higher in smokers than in never-smokers. Serum levels of FGF-21 increased and correlated with alanine transaminase, γ guanosine-5′-triphosphate, and total cholesterol only in smokers, suggesting FGF-21 as a metabolic disorder-related factor in smokers. In aged men (60.3 ± 1.7 years), although the serum levels of sαKl in never-smokers were low, smokers showed highly increased serum levels of sαKl. Serum levels of sαKl was correlated with IL-6 in middle-aged never-smokers, suggesting sαKl regulates IL-6. However, this correlation was disrupted in smokers and aged men.