State-dependent bidirectional modification of somatic inhibition in neocortical pyramidal cells
State-dependent bidirectional modification of somatic inhibition in neocortical pyramidal cells
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DOI：
10.1016/j.neuron.2008.01.030
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发表时间：
2008-03-27
期刊：
影响因子：
16.2
通讯作者：
Komatsu, Yukio
中科院分区：
文献类型：
--
作者：
Kurotani, Tohru;Yamada, Kazumasa;Komatsu, Yukio
皮层锥体神经元根据行为状态改变对输入信号的反应。我们研究了体细胞抑制的变化是否有助于这些改变。在大鼠视觉皮层第5层锥体神经元中，来自去极化膜电位的重复放电通常发生在觉醒期间，产生持久的躯体抑制抑制。相反，通常发生在慢波睡眠期间的去极化阶段的慢膜振荡会产生持久的增强。抑制是由l型Ca2+通道和GABAA受体内吞作用介导的，而增强是由r型Ca2+通道和受体胞外作用介导的。可能修饰的方向主要取决于R型和l型Ca2+通道激活的比例。此外，在慢波睡眠时制备的大鼠切片中，体细胞抑制比觉醒时更强。这种体细胞抑制的双向修饰可能根据行为状态改变锥体神经元的反应性。
Cortical pyramidal neurons alter their responses to input signals depending on behavioral state. We investigated whether changes in somatic inhibition contribute to these alterations. In layer 5 pyramidal neurons of rat visual cortex, repetitive firing from a depolarized membrane potential, which typically occurs during arousal, produced long-lasting depression of somatic inhibition. In contrast, slow membrane oscillations with firing in the depolarized phase, which typically occurs during slow-wave sleep, produced long-lasting potentiation. The depression is mediated by L-type Ca2+ channels and GABAA receptor endocytosis, whereas potentiation is mediated by R-type Ca2+ channels and receptor exocytosis. It is likely that the direction of modification is mainly dependent on the ratio of R- and L-type Ca2+ channel activation. Furthermore, somatic inhibition was stronger in slices prepared from rats during slow-wave sleep than arousal. This bidirectional modification of somatic inhibition may alter pyramidal neuron responsiveness in accordance with behavioral state.