Synthesis of fused oxazole-containing coumarin derivatives via oxidative cross coupling reaction using a combination of CuCl2 and TBHP
Synthesis of fused oxazole-containing coumarin derivatives via oxidative cross coupling reaction using a combination of CuCl2 and TBHP
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DOI：
10.1039/c5ra27993c
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发表时间：
2016-02
期刊：
影响因子：
3.9
通讯作者：
Md. Belal;A. Khan
中科院分区：
文献类型：
--
作者：
Md. Belal;A. Khan
以20mol%CuCl2为催化剂，TBHP为氧化剂，通过氧化交叉偶联反应合成了含香豆素衍生物的稠合恶唑。该反应通过C-H键通过交叉偶联（CDC）途径的官能化进行，以产生各种恶唑衍生物。该反应方案在室温下从各种3-（苄基氨基）-2H-苯并吡喃-2-酮衍生物容易地获得许多含有香豆素部分的恶唑衍生物。
Various fused oxazoles containing coumarin derivatives were synthesized via an oxidative cross coupling reaction by employing 20 mol% CuCl2 as the catalyst and TBHP as an oxidant. The reaction proceeds through functionalization of a C–H bond by a cross-dehydrogenative coupling (CDC) pathway to produce various oxazole derivatives. The reaction protocol gives easy access to a number of oxazole derivatives containing the coumarin moiety at room temperature from various 3-(benzylamino)-2H-chromen-2-one derivatives.