THE EAGLE EFFECT REVISITED - EFFICACY OF CLINDAMYCIN, ERYTHROMYCIN, AND PENICILLIN IN THE TREATMENT OF STREPTOCOCCAL MYOSITIS
THE EAGLE EFFECT REVISITED - EFFICACY OF CLINDAMYCIN, ERYTHROMYCIN, AND PENICILLIN IN THE TREATMENT OF STREPTOCOCCAL MYOSITIS
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DOI：
10.1093/infdis/158.1.23
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发表时间：
1988-07-01
影响因子：
6.4
通讯作者：
WINN, V
中科院分区：
文献类型：
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作者：
STEVENS, DL;GIBBONS, AE;WINN, V
我们研究了青霉素、克林霉素和红霉素在化脓性链球菌引起的小鼠肌炎模型中的相对疗效。青霉素是无效的，除非在细菌注射时给予，治疗延迟2小时降低其疗效，使生存率并不比未治疗的对照动物好（P > 0.05）。红霉素治疗的小鼠的存活率高于青霉素治疗的小鼠和未治疗的对照组，但仅当治疗在2小时内开始时。然而，接受克林霉素的小鼠，即使治疗延迟0，2，6和16.5小时，存活率分别为100%，100%，80%和70%。因此，在所有不同的治疗组中，克林霉素表现出上级疗效优于青霉素（P <0.05）。我们的研究结果证实了青霉素在链球菌感染模型中的失败，并表明，与青霉素不同，克林霉素的疗效不会因“鹰效应”而发生不良改变。".
We investigated the relative efficacies of penicillin, clindamycin, and erythromycin in a mouse model of myositis due to Streptococcus pyogenes. Penicillin was ineffective unless given at the time of bacterial injection, and treatment delays of 2 h reduced its efficacy such that survival was no better than that of untreated control animals (P > .05). Survival of erythromycin-treated mice was greater than that of both penicillin-treated mice and untreated controls, but only if treatment was begun with 2 h. Mice receiving clindamycin, however, had survival rates of 100%, 100%, 80%, and 70% even if treatment was delayed 0, 2, 6, and 16.5 h, respectively. Thus, clindamycin demonstrated superior efficacy to penicillin among all the various treatment groups (P < .05). Our results corroborate the failure of penicillin in this model of streptococcal infection and suggest that, unlike penicillin, the efficacy of clindamycin is not adversly altered by the "Eagle effect.".