Anti-diabetic effect of baicalein is associated with the modulation of gut microbiota in streptozotocin and high-fat-diet induced diabetic rats
Anti-diabetic effect of baicalein is associated with the modulation of gut microbiota in streptozotocin and high-fat-diet induced diabetic rats
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DOI：
10.1016/j.jff.2018.04.070
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发表时间：
2018-07-01
影响因子：
5.6
通讯作者：
Dong, Yuesheng
中科院分区：
文献类型：
--
作者：
Zhang, Bowei;Sun, Wenlong;Dong, Yuesheng
黄芩素是一种膳食黄酮，是亚洲、欧洲和美国作为茶或膳食补充剂消费的木蝴蝶和黄芩的主要成分。尽管其生物利用度有限，但该化合物表现出多种生物活性。在本研究中，黄芩素治疗4周可显著降低STZ和高脂高糖饮食诱导的糖尿病大鼠的血糖和循环脂多糖（LPS）水平，改善胰岛素抵抗、炎症和血脂水平。这些抗糖尿病作用归因于SCFAs含量的增加和肠道粘液层厚度的增加，并且与肠道微生物群的调节有关。在关键代谢表型中，类杆菌和类杆菌目S24-7在高剂量黄芩素组中相对丰度最高，且与2型糖尿病（T2 DM）改善相关表型呈正相关。我们的研究支持使用黄芩素作为膳食补充剂和潜在的益生元，因为它能够改变肠道微生物群并改善T2 DM相关的生化异常。
Baicalein, a dietary fiavonoid, is the major constituent of Oroxylum indicum and Scutellaria baicalensis which are consumed as teas or dietary supplements in Asia, European, and the United States. The compound exhibits a variety of bioactivities despite its limited bioavailability. In the present work, 4-week treatment of baicalein significantly decreased the levels of blood glucose and circulating lipopolysaccharide (LPS) and improved insulin resistance, inflammation, and lipid profile in diabetic rats induced by STZ and high-fat-high-sugar-diet. These anti-diabetic effects were attributed to the increased SCFAs content and the increased thickness of gut mucus layer, and were associated with the modulation of gut microbiota. Among the key phylotypes, Bacteroides and Bacteroidales S24-7 had the highest relative abundance in the rats receiving high-dose baicalein and showed positive correlation with the phenotypes related to the improvement of type 2 diabetes (T2DM). Our study supports the use of baicalein as a dietary supplement and a potential prebiotic for its ability to modify gut microbiota and to improve T2DM-related biochemical abnormalities.