Cutting edge: The prevalence of regulatory T cells lymphoid tissue is correlated with viral load HIV-infected patients
Cutting edge: The prevalence of regulatory T cells lymphoid tissue is correlated with viral load HIV-infected patients
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DOI：
10.4049/jimmunol.174.6.3143
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发表时间：
2005-03-15
影响因子：
4.4
通讯作者：
Chougnet, CA
中科院分区：
文献类型：
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作者：
Andersson, J;Boasso, A;Chougnet, CA
局部细胞介导的免疫力不足似乎对建立慢性HIV感染至关重要。调节性T细胞（T-reg）在HIV复制部位（淋巴器官）的积累可能会影响HIV感染的结果。我们的数据提供了慢性HIV感染改变T-reg组织分布的首次证据。与抗逆转录病毒治疗的患者相比，未治疗患者的扁桃体中T-reg的几种分子特征（FoxP 3、CTLA-4、糖皮质激素诱导的TNFR家族相关受体和CD 25）表达更多。重要的是，大多数FoxP 3（+）细胞表达CTLA-4，但不表达CD 69。此外，FoxP 3水平和病毒载量之间的直接相关性是明显的。相比之下，FoxP 3表达在未经治疗的患者的循环T细胞中降低，但在开始治疗后恢复正常。未经治疗的患者扁桃体中T-reg活性的功能标志物（吲哚胺2，3-双加氧酶、TGF-β和CD 80）显著增加。我们的数据可以为基于免疫的治疗提供新的基础，这些治疗可以抵消体内T-reg，从而加强适当的抗病毒免疫。
Inadequate local cell-mediated immunity appears crucial for the establishment of chronic HIV infection. Accumulation of regulatory T cells (T-reg) at the site of HIV replication, the lymphoid organs, may influence the outcome of HIV infection. Our data provide the first evidence that chronic HIV infection changes T-reg tissue distribution. Several molecules characteristics of T-reg (FoxP3, CTLA-4, glucocorticoid-induced TNFR family-related receptor, and CD25) were expressed more in tonsils of untreated patients compared with antiretroviral-treated patients. Importantly, most FoxP3(+) cells expressed CTLA-4, but not CD69. Furthermore, a direct correlation between FoxP3 Levels and viral load was evident. In contrast, FoxP3 expression was decreased in circulating T cells from untreated patients, but normalized after initiation of treatment. Functional markers of T-reg activity (indoleamine 2,3-dioxygenase, TGF-beta, and CD80) were markedly increased in the tonsils of untreated patients. Our data could provide a new basis for immune-based therapies that counteract in vivo T-reg and thereby reinforce appropriate antiviral immunity.