Targeted delivery for musculoskeletal diseases.
Targeted delivery for musculoskeletal diseases.
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肌肉骨骼疾病的靶向给药。
DOI：
10.1007/s11095-008-9716-y
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发表时间：
2008
影响因子：
3.7
通讯作者：
Wang,Dong
中科院分区：
文献类型：
--
作者：
Wang,Dong
肌肉骨骼系统由骨骼、肌肉、肌腱和韧带组成。作为人体解剖学的重要组成部分，它作为身体的机械支撑，保护重要器官和骨髓。它还作为离子储备，特别是钙和磷酸盐，用于维持血清稳态。骨骼与附着的肌肉、韧带和肌腱的协调为人体提供运动。肌肉骨骼系统的任何组成部分的功能障碍都可能导致各种形式的疾病。例如，有利于骨吸收的不平衡的骨重塑导致骨质疏松症，骨质疏松症是一种以低骨量和骨组织的微结构退化为特征的疾病，导致骨折风险增加。风湿性关节炎，另一方面，是一种自身免疫性疾病，损害关节骨和软骨，造成显着的疼痛和运动的损失。此外，几种类型的癌症以骨作为其主要转移部位。由于骨感染金黄色葡萄球菌引起的骨髓炎很难治疗，有时必须通过手术清创甚至截肢来解决。
The musculoskeletal system is composed of bone, muscles, tendons, and ligaments. As an essential component of the human anatomy, it serves as the mechanical support for the body and protects vital organs and bone marrow. It also serves as a reserve of ions, especially calcium and phosphate, for the maintenance of serum homeostasis. The coordination of the skeleton with attached muscles, ligaments, and tendons provides locomotion for the human body.Dysfunction of any component of the musculoskeletal system can cause various forms of diseases. As an example, imbalanced bone remodeling favoring bone resorption leads to osteoporosis, a disease characterized by low bone mass and micro-architectural deterioration of bone tissue resulting in an increased fracture risk. Rheumatoid arthritis, on the other hand, is an autoimmune disorder that damages both articular bone and cartilage, causing significant pain and loss of movement. Furthermore, several types of cancer have bone as their primary sites of metastasis. Osteomyelitis due to bone infection of Staphylococcus aureus is hard to treat and sometimes has to be resolved with surgical debridement or even amputation.