Chloride-dominant salt sensitivity in the stroke-prone spontaneously hypertensive rat.
Chloride-dominant salt sensitivity in the stroke-prone spontaneously hypertensive rat.
复制标题
易发生中风的自发性高血压大鼠中以氯为主的盐敏感性。
DOI：
10.1161/01.hyp.0000164628.46415.66
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
MorrisJr,RCurtis
中科院分区：
文献类型：
--
作者：
Schmidlin,Olga;Tanaka,Masae;Bollen,AndrewW;Yi,Sai-Li;MorrisJr,RCurtis
We tested the hypothesis that in the stroke-prone spontaneously hypertensive rat (SHRSP), the Cl−component of dietary NaCl dominantly determines its pressor effect (salt-sensitivity). We telemetrically measured systolic aortic blood pressure (SBP) in SHRSP loaded with: nothing (CTL); NaCl alone (NaCl) (44 mmol/100 grams chow); KCl (KCl) alone (44 mmol); NaCl (44 mmol) combined with KHCO3(77 mmol) (NaCl/KBC) or with KCl (77 mmol) (NaCl/KCl). Across all groups, from age 10 to 15 or 16 weeks, SBP increased linearly (mm Hg/week) (dp/dt, change in SBP as a function of time): CTL, 5.6; NaCl, 9.5; KCl, 8.8; NaCl/KBC, 9.1; and NaCl/KCl, 14.6. Thus, the value of dp/dt in KCl matched that in NaCl. The value of dp/dt in NaCl/KCl exceeded that in NaCl in direct proportion to the greater Cl−load. Across all groups, only Cl−load bore a direct, highly linear relationship with dp/dt. Strokes occurred only, but always with SBP >250 mm Hg, a value observed almost exclusively in NaCl/KCl. Thus, Cl−dominantly determined the pressor effect induced with dietary NaCl, both with NaCl loaded alone and combined with either KCl or KHCO3, and thereby likely determined the occurrence of stroke with NaCl loading. Over the initial 3-day period of NaCl loading and exacerbating hypertension, external balance of Na+increased similarly among all groups. However, within 24 hours of initiating NaCl loading, urinary creatinine excretion decreased in direct proportion to dp/dt and urinary Cl−excretion. We conclude that in the SHRSP, the Cl−component of a dietary NaCl dominantly determines salt sensitivity and thereby phenotypic expression. We suggest that Cl−might do so by inducing renal vasoconstriction.
