Attenuation of noise in ultrasensitive signaling cascades
Attenuation of noise in ultrasensitive signaling cascades
复制标题
DOI：
10.1016/s0006-3495(02)75635-x
复制
发表时间：
2002-06-01
影响因子：
3.4
通讯作者：
van Oudenaarden, A
中科院分区：
文献类型：
--
作者：
Thattai, M;van Oudenaarden, A
超灵敏级联通常在细胞信号传导和基因调控网络中实现阈值操作，将分级输入信号转换为离散的全或无输出。然而，这种级联中涉及的生化和遗传反应受到随机波动的影响，导致输出信号电平中存在噪声。在这里，我们证明了在饱和附近工作的级联的输出信号波动在幅度上是有界的，即使噪声级联级的数量变得很大。我们表明这些波动有界级联可以用来衰减输入信号中的噪声，并且我们找到了实现最佳降噪所需的最佳级联长度。具有超灵敏传递函数的级联自然地在饱和附近运行，并且可以同时实现阈值和降噪。因此，它们非常适合在自然和人工生物网络中介导信号传递。
Ultrasensitive cascades often implement thresholding operations in cell signaling and gene regulatory networks, converting graded input signals into discrete all-or-none outputs. However, the biochemical and genetic reactions involved in such cascades are subject to random fluctuations, leading to noise in output signal levels. Here we prove that cascades operating near saturation have output signal fluctuations that are bounded in magnitude, even as the number of noisy cascade stages becomes large. We show that these fluctuation-bounded cascades can be used to attenuate the noise in an input signal, and we find the optimal cascade length required to achieve the best possible noise reduction. Cascades with ultrasensitive transfer functions naturally operate near saturation, and can be made to simultaneously implement thresholding and noise reduction. They are therefore ideally suited to mediate signal transfer in both natural and artificial biological networks.