MYOGLOBIN IN RAT HINDLIMB MUSCLES AFTER DENERVATION AND DURING REINNERVATION
MYOGLOBIN IN RAT HINDLIMB MUSCLES AFTER DENERVATION AND DURING REINNERVATION
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DOI：
10.1002/mus.880070811
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发表时间：
1984-01-01
期刊：
影响因子：
3.4
通讯作者：
ROXIN, LE
中科院分区：
文献类型：
--
作者：
ASKMARK, H;CARLSON, M;ROXIN, LE
用放射免疫法测定了大鼠坐骨神经手术失神经支配后和冷冻损伤后再神经支配时后肢肌肉肌红蛋白（Mb）的含量。对侧腿的肌肉作为对照。坐骨神经切除后第4天，胫骨前肌、腓骨长肌和趾长伸肌红蛋白浓度下降。此后，水平升高，直至第32天的末次观察。胫骨前肌和趾长伸肌肌中肌红蛋白水平的增加（分别为305%和324%）比腓骨长肌和比目鱼肌（分别为148%和137%）明显得多。坐骨神经冷冻损伤后，胫骨前肌、腓骨长肌和趾长伸肌肌中的Mb浓度增加，在第16-21天达到最大值。随后水平下降，2个月观察到正常值。手术后。神经再支配期间Mb水平的正常化与先前研究中观察到的临床恢复和神经生理学结果在时间上相当一致。
Radioimmunoassay of myoglobin (Mb) was performed in rat hind limb muscles afer surgical denervation and during reinnervation following cryolesion of the sciatic nerve. Muscles of the contralateral leg served as controls. After resection of the sciatic nerve, decreased Mb concentrations were noted on the 4th day in the tibialis anterior, peroneus longus and extensor digitorum longus (EDL) muscles. Thereafter, the levels increased up to the last observation on day 32. The increases in Mb levels in the tibialis anterior and EDL muscles were considerably more pronounced (305% and 324%, respectively) than in the peroneus longus and soleus muscles (148% and 137%, respectively). After cryolesion of the sciatic nerve, the Mb concentrations in the tibialis anterior, peroneus longus and EDL muscles increased, reaching maximal values on days 16-21. The levels then decreased and normal values were observed 2 mo. postoperatively. The normalization of the Mb levels during reinnervation corresponded fairly well in time with the clinical recovery and neurophysiological findings observed in a previous study.