Adenomatous polyposis coli as a predictor of environmental chemical-induced transgenerational effects related to male infertility
Adenomatous polyposis coli as a predictor of environmental chemical-induced transgenerational effects related to male infertility
复制标题
腺瘤性大肠杆菌作为环境化学诱导的与男性不育相关的跨代效应的预测因子
DOI：
10.1002/jbt.22331
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发表时间：
2019-07-01
影响因子：
3.6
通讯作者：
Wang，Xinru
中科院分区：
文献类型：
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作者：
Yuan，Beilei;Wu，Wei;Wang，Xinru
怀孕期间接触有毒环境化学品是对健康的普遍威胁，可能会造成跨代后果。然而，作为环境化学品接触的一部分，代际效应如何发生的根本机制还没有得到很好的理解。我们研究了潜在的分子变化与邻苯二甲酸酯暴露，诱导跨代效应，使用大鼠模型。通过对Gene Expression Omnibus数据库的分析，我们发现了一些类似的环境暴露引起跨代效应的研究。然后，我们分析了其中一项研究和我们的结果，以确定腺瘤性结肠息肉病（APC）基因。该基因参与了大多数途径，并在两项研究中上调。我们使用miRWALK数据集来预测靶向APC基因的microRNA。我们证实miR-30家族在F3睾丸组织中显著下调，并靶向APC基因。总之，miR-30家族/APC相互作用是环境化学物质诱导的跨代效应的潜在机制。
Exposure to toxic environmental chemicals during pregnancy is a ubiquitous threat to health with potentially transgenerational consequences. However, the underlying mechanism of how transgenerational effects occur as part of environmental chemical exposure are not well understood. We investigated the potential molecular changes associated with dibutyl phthalate exposure that induced transgenerational effects, using a rat model. Through the analysis of the Gene Expression Omnibus database, we found some similar studies of environmental exposure induced transgenerational effects. Then, we analyzed one of the studies and our results to identify the adenomatous polyposis coli (APC) gene. This gene participated the most of the pathways and was upregulated in both studies. We used the miRWALK data set to predict the microRNAs which targeted the APC gene. We confirmed the miR‐30 family were significantly downregulated in F3 testis tissues and targeted the APC gene. In conclusion, the miR‐30 family/APC interaction is a potential mechanism for the transgenerational effects induced by the environmental chemical.