Cooperation and competition between the dorsal hippocampus and lateral amygdala in spatial discrimination learning
Cooperation and competition between the dorsal hippocampus and lateral amygdala in spatial discrimination learning
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DOI：
10.1002/hipo.20187
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发表时间：
2006-01-01
期刊：
影响因子：
3.5
通讯作者：
White, Norman M.
中科院分区：
文献类型：
--
作者：
Gaskin, Stephane;White, Norman M.
用条件性线索偏爱(CCP)研究大鼠在放射状迷宫中如何分辨相邻的手臂。Chai和White(Behav Neurosci 2004,118：770-784)表明，学习这种辨别需要完整的背侧海马体，并且同时获得基于杏仁核的条件性接近反应，产生相同的进入双臂的倾向。在目前的实验中，大鼠被预先暴露在没有食物的迷宫中，并通过交替将它们限制在两个相邻手臂的末端进行训练，一个手臂包含食物，另一个不包含食物。当让老鼠在没有食物的手臂之间进行选择时，老鼠在与食物配对的手臂上花费的时间更多，这表明它们已经学会了辨别自己的位置。在有食物配对的手臂上，在禁闭期间用麝香酚暂时使背侧海马区失活对辨别能力没有影响，但在没有食物的手臂上暂时失活会削弱这种辨别能力。在杏仁核受损的大鼠中，这种效应模式被逆转(食物配对的手臂上的失活受损，但非食物手臂上的失活对辨别没有影响)，表明在这种情况下，基于海马体的学习和基于杏仁核的学习相互作用，影响正常大鼠的行为。背侧海马体了解到有食物的地方和没有食物的地方。基于杏仁核的进入食物配对手臂的倾向与基于海马体的在食物配对的手臂上寻找食物的倾向合作，但基于杏仁核的进入无食物手臂的倾向与基于海马体的关于该手臂上没有食物的学习相竞争。(C)2006年Wiley-Liss，Inc.
The conditioned cue preference (CCP) was used to study how rats discriminate between adjacent arms on a radial maze. Chai and White (Behav Neurosci 2004, 118:770-784) showed that an intact dorsal hippocampus is required to learn this discrimination and that an amygdala-based conditioned approach response that produces an equal tendency to enter both arms is simultaneously acquired. In the present experiments, rats were preexposed to the maze with no food and trained by alternately confining them at the ends of two adjacent arms, one that contained food and one that did not. When given a choice between these arms with no food present, the rats spent more time on their food-paired arms, suggesting they had learned to discriminate their locations. Temporary inactivation of the dorsal hippocampus with muscimol during confinement on the food-paired arm had no effect on the discrimination, but inactivation while on the no-food arm impaired it. This pattern of effects was reversed in rats with amygdala lesions (inactivation on the food-paired arm impaired, but inactivation on the no-food arm had no effect on the discrimination), showing that hippocampus-based and amygdala-based learning interact to influence the behavior of normal rats in this situation. The dorsal hippocampus learns about locations that contain food and about locations that do not contain food. The amygdala-based tendency to enter the food-paired arm cooperates with hippocampus-based foraging for food on the food-paired, but the amygdala-based tendency to enter the no-food arm competes with hippocampus-based learning about the absence of food on that arm. (c) 2006 Wiley-Liss, Inc.