Acute Kidney Injury and Cardiovascular Outcomes in Acute Severe Hypertension
Acute Kidney Injury and Cardiovascular Outcomes in Acute Severe Hypertension
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DOI：
10.1161/circulationaha.109.896597
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发表时间：
2010-05-25
期刊：
影响因子：
37.8
通讯作者：
Varon, Joseph
中科院分区：
文献类型：
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作者：
Szczech, Lynda A.;Granger, Christopher B.;Varon, Joseph
背景-目前对肾功能不全与急性重度高血压预后的关系知之甚少。本研究旨在测量基线慢性肾脏疾病与（估计肾小球滤过率），急性肾损伤（阿基，估计肾小球滤过率从基线降低>= 25%）和急性重度高血压住院患者的结果。方法和结果-研究急性高血压治疗（STAT）登记处招募了急性重度高血压患者，定义为≥ 1次血压测量值收缩压>180 mm Hg和/或舒张压>110 mm Hg，并接受静脉降压治疗。按入院时估计的肾小球滤过率和入院时的阿基对各组数据进行比较。入院时，79%的队列（n = 1566）至少有轻度慢性肾脏疾病（估计肾小球滤过率
Background-Little is known about the association of kidney dysfunction and outcome in acute severe hypertension. This study aimed to measure the association between baseline chronic kidney disease (estimated glomerular filtration rate), acute kidney injury (AKI, decrease in estimated glomerular filtration rate >= 25% from baseline) and outcome in patients hospitalized with acute severe hypertension.Methods and Results-The Studying the Treatment of Acute Hypertension (STAT) registry enrolled patients with acute severe hypertension, defined as >= 1 blood pressure measurement >180 mm Hg systolic and/or >110 mm Hg diastolic and treated with intravenous antihypertensive therapy. Data were compared across groups categorized by admission estimated glomerular filtration rate and AKI during admission. On admission, 79% of the cohort (n = 1566) had at least mild chronic kidney disease (estimated glomerular filtration rate