The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy.
The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy.
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反向瓦尔堡效应可能是癌症的致命弱点，可用于癌症治疗
DOI：
10.18632/oncotarget.18175
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发表时间：
2017-08-22
期刊：
影响因子：
--
通讯作者：
Zhou M
中科院分区：
文献类型：
--
作者：
Fu Y;Liu S;Yin S;Niu W;Xiong W;Tan M;Li G;Zhou M
尽管在过去的几十年里，通过常规化疗和靶向治疗，癌症患者的生存结局得到了显着改善，但仍存在一些坚韧的临床挑战，如抗癌药物耐药性，不可避免的复发，癌症进展和转移。与此同时，越来越多的证据表明，糖代谢异常的肿瘤细胞中的“瓦尔堡效应”是密切相关的恶性表型。2009年，一个新的“二室代谢偶联”模型，也被称为“逆瓦尔堡效应”，被提出并引起了广泛的关注。基于这一新的模型，我们考虑是否可以利用这一新的观点来改进现有的抗癌治疗策略。本文综述了从“瓦尔堡效应”到“反向瓦尔堡效应”的研究范式转变、“反向瓦尔堡效应”的特点和分子机制，并讨论了其在基础研究和临床实践中的意义。
Although survival outcomes of cancer patients have been improved dramatically via conventional chemotherapy and targeted therapy over the last decades, there are still some tough clinical challenges that badly needs to be overcome, such as anticancer drug resistance, inevitable recurrences, cancer progression and metastasis. Simultaneously, accumulated evidence demonstrates that aberrant glucose metabolism termed ‘the Warburg effect’ in cancer cell is closely associated with malignant phenotypes. In 2009, a novel ‘two-compartment metabolic coupling’ model, also named ‘the reverse Warburg effect’, was proposed and attracted lots of attention. Based on this new model, we consider whether this new viewpoint can be exploited for improving the existent anti-cancer therapeutic strategies. Our review focuses on the paradigm shift from ‘the Warburg effect’ to ‘the reverse Warburg effect’, the features and molecular mechanisms of ‘the reverse Warburg effect’, and then we discuss its significance in fundamental researches and clinical practice.
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DOI：
10.1126/science.1211485
发表时间：
2011-12-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Anastasiou D;Poulogiannis G;Asara JM;Boxer MB;Jiang JK;Shen M;Bellinger G;Sasaki AT;Locasale JW;Auld DS;Thomas CJ;Vander Heiden MG;Cantley LC
通讯作者：
Cantley LC
影响因子：
4.3
作者：
Ertel, Adam;Tsirigos, Aristotelis;Lisanti, Michael P.
通讯作者：
Lisanti, Michael P.
淋巴瘤中HVEM肿瘤抑制剂的丧失和修饰的CAR-T细胞恢复。
影响因子：
64.5
作者：
Boice M;Salloum D;Mourcin F;Sanghvi V;Amin R;Oricchio E;Jiang M;Mottok A;Denis-Lagache N;Ciriello G;Tam W;Teruya-Feldstein J;de Stanchina E;Chan WC;Malek SN;Ennishi D;Brentjens RJ;Gascoyne RD;Cogné M;Tarte K;Wendel HG
通讯作者：
Wendel HG
DOI：
10.1186/bcr3472
发表时间：
2013
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Choi J;Kim DH;Jung WH;Koo JS
通讯作者：
Koo JS
影响因子：
3.6
作者：
Chiavarina, Barbara;Whitaker-Menezes, Diana;Lisanti, Michael P.
通讯作者：
Lisanti, Michael P.