Pathogenesis of painful diabetic neuropathy.
Pathogenesis of painful diabetic neuropathy.
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DOI：
10.1155/2014/412041
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发表时间：
2014
影响因子：
--
通讯作者：
Rajbhandari S
中科院分区：
文献类型：
--
作者：
Aslam A;Singh J;Rajbhandari S
全球糖尿病患病率不断上升，其相关并发症也在不断增加。疼痛性糖尿病神经病变（PDN）是众所周知的糖尿病并发症，也是所有神经性疼痛的最常见原因。大约三分之一的糖尿病患者患有 PDN。它对一个人的日常生活，无论是身体上还是精神上都有巨大的影响。尽管糖尿病和神经病学取得了巨大进展，但 PDN 疼痛的确切机制仍不清楚。疼痛的起源可能是中枢神经系统的周围神经。在这篇综述中，我们讨论了 PDN 疼痛发病机制的各种可能机制。我们讨论高血糖在改变周围神经生理学中的作用。我们还描述了疼痛的中心机制。
The prevalence of diabetes is rising globally and, as a result, its associated complications are also rising. Painful diabetic neuropathy (PDN) is a well-known complication of diabetes and the most common cause of all neuropathic pain. About one-third of all diabetes patients suffer from PDN. It has a huge effect on a person's daily life, both physically and mentally. Despite huge advances in diabetes and neurology, the exact mechanism of pain causation in PDN is still not clear. The origin of pain could be in the peripheral nerves of the central nervous system. In this review, we discuss various possible mechanisms of the pathogenesis of pain in PDN. We discuss the role of hyperglycaemia in altering the physiology of peripheral nerves. We also describe central mechanisms of pain.