Nickel-catalyzed N-arylation of amines with arylboronic acids under open air
Nickel-catalyzed N-arylation of amines with arylboronic acids under open air
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DOI：
10.1016/j.tetlet.2019.04.004
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发表时间：
2019-05-02
影响因子：
1.8
通讯作者：
Ishizuka, Tadao
中科院分区：
文献类型：
--
作者：
Ando, Shin;Hirota, Yurina;Ishizuka, Tadao
在这项研究中，一个定义明确，新颖的NHC-Ni配合物的开发和用于催化N-芳基化的烷基和芳基胺与芳基硼酸在一个罕见的版本的Chan-Lam耦合。虽然使用铜催化剂的相同偶联已被广泛研究，但镍催化的版本很少，通常需要10-20摩尔%的催化剂负载。然而，这种新的NHC-Ni络合物与4，4 ′-二甲基-2，2 ′-联吡啶的组合被证明是有效的催化剂，其将所需的催化剂负载量降低到仅2.0摩尔%。(C)2019爱思唯尔有限公司版权所有。
In this study, a well-defined, novel NHC-Ni complex was developed and used to catalyze the N-arylation of alkyl- and arylamines with arylboronic acids in a rare version of Chan-Lam coupling. Although the same coupling using copper catalysts has been widely studied, the nickel-catalyzed version is rare and normally requires 10-20 mol% catalyst loading. This novel NHC-Ni complex in combination with 4,4'-dimethyl-2,2'-bipyridine, however, proved to be an effective catalyst that lowered the required catalyst loading to only 2.0 mol%. (C) 2019 Elsevier Ltd. All rights reserved.