Degradable magnesium-based alloys for biomedical applications: The role of critical alloying elements
Degradable magnesium-based alloys for biomedical applications: The role of critical alloying elements
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DOI：
10.1177/0885328219834656
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发表时间：
2019-05-01
影响因子：
2.9
通讯作者：
Chen, Chuanzhong
中科院分区：
文献类型：
--
作者：
Chen, Yang;Dou, Jinhe;Chen, Chuanzhong
镁基合金具有生物可降解性、生物相容性和优异的力学性能，是理想的生物医用材料。特别是，它们的生物降解能力有助于患者避免二次手术。然而，腐蚀速度太快，无法维持愈合过程。合金化是减缓腐蚀速率的有效方法。然而，目前作为生物材料的镁合金大多是商业合金，没有从生物安全的角度考虑细胞毒性。本文综述了各种现有的和新开发的专门用于生物医学应用的可降解镁基合金的现状。详细讨论了关键合金元素、成分、热处理和加工工艺对镁合金组织、力学性能和耐蚀性的影响。本文介绍了Mg-Ca基、Mg-Zn基、Mg-Sr基、Mg-RE基和Mg-Cu基合金体系。综述了镁基生物材料的制备和镁基合金表面处理的新方法。
Magnesium-based alloys exhibit biodegradable, biocompatible and excellent mechanical properties which enable them to serve as ideal candidate biomedical materials. In particular, their biodegradable ability helps patients to avoid a second surgery. The corrosion rate, however, is too rapid to sustain the healing process. Alloying is an effective method to slow down the corrosion rate. However, currently magnesium alloys used as biomaterials are mostly commercial alloys without considering cytotoxicity from the perspective of biosafety. This article comprehensively reviews the status of various existing and newly developed degradable magnesium-based alloys specially designed for biomedical application. The effects of critical alloying elements, compositions, heat treatment and processing technology on the microstructure, mechanical properties and corrosion resistance of magnesium alloys are discussed in detail. This article covers Mg-Ca based, Mg-Zn based, Mg-Sr based, Mg-RE based and Mg-Cu-based alloy systems. The novel methods of fabricating Mg-based biomaterials and surface treatment on Mg based alloys for potential biomedical applications are summarized.