The Sympathetic Skin Response Located in the Penis as a Predictor of the Response to Sertraline Treatment in Patients with Primary Premature Ejaculation
The Sympathetic Skin Response Located in the Penis as a Predictor of the Response to Sertraline Treatment in Patients with Primary Premature Ejaculation
复制标题
位于阴茎的交感皮肤反应是原发性早泄患者对舍曲林治疗反应的预测因子
DOI：
10.1111/jsm.12654
复制
发表时间：
2014-11-01
影响因子：
3.5
通讯作者：
Dai, Yutian
中科院分区：
文献类型：
--
作者：
Xia, Jiadong;Chen, Taowei;Dai, Yutian
原发性早泄（primary premature ejaculation，PPE）的发病机制是复杂的、多因素的，交感神经功能亢进是其发病机制之一，目的探讨舍曲林对PPE患者交感神经功能的影响及阴茎交感神经皮肤反应（sympathetic skin response located in the penis，PSSR）对舍曲林治疗PPE的预测价值。每天给予舍曲林50 mg，共8周。在实验前后，对患者进行PSSR测试和性行为参数评估。主要观察指标阴道射精潜伏时间（IELT）、中国早泄指数-5（CIPE-5）、PSSR潜伏期和波幅的变化。结果舍曲林治疗后，PSSR潜伏期和波幅均明显下降，但与对照组相比，差异有统计学意义（P < 0. 05）。58例（95.1%）患者完成了整个研究并进行了分析。舍曲林治疗8周后，与治疗前相比，IELT和CIPE-5评分显著提高（均P
IntroductionThe pathologic mechanisms of primary premature ejaculation (PPE) are complex and multifactorial, and hyperactivity of the sympathetic nervous system is one of the mechanisms.AimTo examine the effects of sertraline on sympathetic nervous system activity and assess the predictive value of the sympathetic skin response located in the penis (PSSR) on the response to sertraline treatment in PPE patients.MethodsSixty-one patients with PPE were recruited. Each received 50mg sertraline daily for 8 weeks. Before and after the experiment, the patients were evaluated for PSSR tests and sexual performance parameters. Additionally, based on the latency of PSSR, we divided the patients into a normal PSSR group and an abnormal PSSR group, and compared the sertraline treatment efficacy between the two groups.Main Outcome MeasuresChanges in intravaginal ejaculation latency time (IELT) and the Chinese premature ejaculation index-5 (CIPE-5), and the latencies and amplitudes of PSSR after sertraline treatment.ResultsOverall, 58 (95.1%) patients completed the entire study and were analyzed. After the 8-week sertraline treatment, compared with those of pretreatment, IELT and CIPE-5 scores were significantly increased (both P