The relationship between body mass index and a plasma lipid peroxidation biomarker in an older, healthy Asian community
The relationship between body mass index and a plasma lipid peroxidation biomarker in an older, healthy Asian community
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DOI：
10.1016/j.annepidem.2004.04.001
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发表时间：
2005-01-01
影响因子：
5.6
通讯作者：
Tsuji, I
中科院分区：
文献类型：
--
作者：
Ohmori, K;Ebihara, S;Tsuji, I
目的：在大量健康的亚洲老年人群中，研究身体质量指数（BMI）与血浆脂质过氧化生物标志物水平之间的关系。这项横断面研究包括2002年居住在社区的1150名70岁或以上的日本人。方法：采用ELISA法测定脂质过氧化生物标志物8-iso-前列腺素F2alpha （8-iso-PGF(2alpha)）。我们还测量了体重和身高，并计算出BMI为体重(kg)/身高（in）。结果：在对潜在混杂因素进行调整后，BMI较高的受试者的平均+/- SE血浆8-iso-PGF（2alpha）水平显著较高：BMI为30.0或更高的受试者的平均+/- 0.8 pg/ml；BMI在25.0 ~ 29.9之间的患者为20.5 +/- 0.3 pg/ml；BMI在18.5 ~ 24.9之间者20.0 +/- 0.2 pg/ml；BMI < 18.5者为19.0 +/- 0.7 pg/ml （p = 0.011）。结论：我们的研究结果表明，在健康的亚洲人群中，BMI与血浆脂质过氧化水平之间存在适度但显著的关系。
PURPOSE: To examine the association between body mass index (BMI) and the plasma level of a lipid peroxidation biomarker in a large sample of elderly healthy Asian population. This cross-sectional study included 1150 community-dwelling Japanese aged 70 years or older in 2002.METHODS: We measured the lipid peroxidation biomarker 8-iso-prostaglandin F2alpha (8-iso-PGF(2alpha)) using the ELISA method. We also measured the weight and height and calculated the BMI as weight (kg)/height (in),.RESULTS: After adjustment for potential confounders, the mean +/- SE plasma 8-iso-PGF(2alpha) level was significantly higher in subjects with higher BMI: 21.1 +/- 0.8 pg/ml in those with BMI of 30.0 or more; 20.5 +/- 0.3 pg/ml in those with BMI between 25.0 and 29.9; 20.0 +/- 0.2 pg/ml in those with BMI between 18.5 and 24.9; and 19.0 +/- 0.7 pg/ml in those with BMI of less than 18.5 (p for trend = 0.011).CONCLUSIONS: Our results demonstrated that in the healthy Asian population, there was a modest but significant relationship between BMI and the plasma lipid peroxidation level.